GUCY1A3 [The Human Chemical-Genetic Interaction Map Project]

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======= GUCY1A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GUCY1A1
  * **<color #00a2e8>Official Name</color>**: guanylate cyclase 1 soluble subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2982|2982]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02108|Q02108]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GUCY1A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GUCY1A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139396|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Guanylate cyc|
|HNOBA|
|HNOB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission|
|response to defense-related host nitric oxide production|
|response to defense-related nitric oxide production by other organism involved in symbiotic interaction|
|trans-synaptic signaling by soluble gas, modulating synaptic transmission|
|retrograde trans-synaptic signaling by soluble gas|
|guanylate cyclase complex, soluble|
|trans-synaptic signaling by nitric oxide, modulating synaptic transmission|
|retrograde trans-synaptic signaling by nitric oxide|
|synaptic signaling by nitric oxide|
|trans-synaptic signaling by nitric oxide|
|trans-synaptic signaling by soluble gas|
|positive regulation of nitric oxide mediated signal transduction|
|response to host immune response|
|response to immune response of other organism involved in symbiotic interaction|
|response to defenses of other organism involved in symbiotic interaction|
|response to host|
|retrograde trans-synaptic signaling|
|response to host defenses|
|relaxation of vascular smooth muscle|
|relaxation of smooth muscle|
|guanylate cyclase activity|
|regulation of nitric oxide mediated signal transduction|
|cGMP biosynthetic process|
|trans-synaptic signaling, modulating synaptic transmission|
|negative regulation of smooth muscle contraction|
|cGMP metabolic process|
|nitric oxide mediated signal transduction|
|relaxation of muscle|
|cyclic nucleotide biosynthetic process|
|negative regulation of muscle contraction|
|cyclic purine nucleotide metabolic process|
|vasodilation|
|cyclic nucleotide metabolic process|
|positive regulation of blood vessel diameter|
|regulation of smooth muscle contraction|
|GABA-ergic synapse|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|heme binding|
|purine ribonucleotide biosynthetic process|
|interaction with host|
|purine nucleotide biosynthetic process|
|regulation of muscle contraction|
|ribonucleotide biosynthetic process|
|vascular process in circulatory system|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|regulation of blood pressure|
|signaling receptor activity|
|regulation of muscle system process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|muscle system process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|purine-containing compound metabolic process|
|GTP binding|
|blood circulation|
|circulatory system process|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|synaptic signaling|
|regulation of anatomical structure size|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|regulation of system process|
|carbohydrate derivative biosynthetic process|
|symbiotic process|
|interspecies interaction between organisms|
|organophosphate metabolic process|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.85|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.77|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15419
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GUCY1A3 Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>