H2AFY [The Human Chemical-Genetic Interaction Map Project]

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======= H2AFY =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MACROH2A1
  * **<color #00a2e8>Official Name</color>**: macroH2A.1 histone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9555|9555]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75367|O75367]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=H2AFY&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20H2AFY|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610054|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). {ECO:0000269|PubMed:12718888, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16107708, ECO:0000269|PubMed:16428466}. Isoform 2: Represses SOD3 gene expression. {ECO:0000269|PubMed:23022728}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Macro|
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein localization to chromosome, telomeric region|
|negative regulation of histone phosphorylation|
|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|regulation of chromatin silencing at rDNA|
|positive regulation of maintenance of sister chromatid cohesion|
|positive regulation of maintenance of mitotic sister chromatid cohesion|
|rDNA binding|
|negative regulation of histone H3-K27 methylation|
|double-stranded methylated DNA binding|
|negative regulation of histone H3-K4 methylation|
|negative regulation of transcription by RNA polymerase I|
|Barr body|
|sex chromatin|
|regulation of maintenance of mitotic sister chromatid cohesion|
|regulation of maintenance of sister chromatid cohesion|
|establishment of protein localization to chromatin|
|protein serine/threonine kinase inhibitor activity|
|positive regulation of sister chromatid cohesion|
|regulation of histone H3-K27 methylation|
|regulation of histone phosphorylation|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|regulation of protein localization to chromosome, telomeric region|
|pericentric heterochromatin|
|establishment of protein localization to chromosome|
|positive regulation of keratinocyte differentiation|
|positive regulation of mitotic sister chromatid segregation|
|dosage compensation|
|negative regulation of histone methylation|
|regulation of sister chromatid cohesion|
|protein localization to chromatin|
|positive regulation of epidermal cell differentiation|
|regulation of histone H3-K4 methylation|
|condensed chromosome|
|nuclear chromosome|
|positive regulation of chromosome segregation|
|regulation of transcription by RNA polymerase I|
|RNA polymerase II core promoter sequence-specific DNA binding|
|regulation of chromatin silencing|
|positive regulation of epidermis development|
|negative regulation of histone modification|
|regulation of keratinocyte differentiation|
|nucleosomal DNA binding|
|promoter-specific chromatin binding|
|positive regulation of mitotic nuclear division|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|negative regulation of chromatin organization|
|protein localization to chromosome|
|positive regulation of gene expression, epigenetic|
|regulation of histone methylation|
|positive regulation of nuclear division|
|nucleosome|
|regulation of mitotic sister chromatid segregation|
|chromatin DNA binding|
|regulation of sister chromatid segregation|
|negative regulation of gene expression, epigenetic|
|regulation of response to oxidative stress|
|regulation of epidermis development|
|negative regulation of cell cycle G2/M phase transition|
|regulation of chromosome segregation|
|nuclear chromosome, telomeric region|
|negative regulation of cellular protein localization|
|nucleosome assembly|
|regulation of gene silencing|
|negative regulation of protein serine/threonine kinase activity|
|chromatin assembly|
|negative regulation of chromosome organization|
|regulation of epithelial cell differentiation|
|regulation of histone modification|
|positive regulation of mitotic cell cycle|
|chromatin assembly or disassembly|
|nucleosome organization|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|DNA packaging|
|regulation of chromatin organization|
|regulation of nuclear division|
|protein-DNA complex assembly|
|regulation of cell cycle G2/M phase transition|
|transcription regulatory region DNA binding|
|negative regulation of protein kinase activity|
|negative regulation of cell cycle phase transition|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|positive regulation of cell cycle process|
|DNA conformation change|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of cell cycle process|
|enzyme binding|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|establishment of protein localization to organelle|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|protein kinase binding|
|protein heterodimerization activity|
|regulation of protein serine/threonine kinase activity|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|chromatin organization|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|regulation of cellular localization|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.04|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='H2AFY Expression in NALM6 Cells: 8.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>