HAMP [The Human Chemical-Genetic Interaction Map Project]

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======= HAMP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HAMP
  * **<color #00a2e8>Official Name</color>**: hepcidin antimicrobial peptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57817|57817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P81172|P81172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HAMP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HAMP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606464|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). {ECO:0000269|PubMed:22306005}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hepcidin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of iron ion transmembrane transport|
|cellular response to bile acid|
|response to iron ion starvation|
|negative regulation of iron ion transport|
|negative regulation of intestinal absorption|
|response to bile acid|
|regulation of iron ion transmembrane transport|
|apical cortex|
|response to erythropoietin|
|regulation of iron ion transport|
|positive regulation of cell growth involved in cardiac muscle cell development|
|multicellular organismal iron ion homeostasis|
|regulation of intestinal absorption|
|cellular response to X-ray|
|regulation of cell growth involved in cardiac muscle cell development|
|positive regulation of cardiac muscle cell differentiation|
|negative regulation of digestive system process|
|response to vitamin A|
|positive regulation of cardiocyte differentiation|
|response to X-ray|
|positive regulation of cardiac muscle hypertrophy|
|liver regeneration|
|positive regulation of muscle hypertrophy|
|cellular response to interleukin-6|
|positive regulation of cardiac muscle tissue growth|
|response to iron ion|
|response to interleukin-6|
|regulation of cardiac muscle cell differentiation|
|positive regulation of heart growth|
|defense response to fungus|
|acute-phase response|
|regulation of digestive system process|
|positive regulation of cardiac muscle tissue development|
|intercalated disc|
|positive regulation of organ growth|
|response to fungus|
|killing of cells of other organism|
|regulation of cardiocyte differentiation|
|disruption of cells of other organism|
|response to zinc ion|
|regulation of cardiac muscle hypertrophy|
|positive regulation of striated muscle cell differentiation|
|regulation of cardiac muscle tissue growth|
|regulation of muscle hypertrophy|
|cellular iron ion homeostasis|
|regulation of heart growth|
|cellular response to ionizing radiation|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|acute inflammatory response|
|animal organ regeneration|
|regulation of cardiac muscle tissue development|
|iron ion homeostasis|
|negative regulation of cation transmembrane transport|
|regulation of muscle adaptation|
|positive regulation of muscle cell differentiation|
|response to vitamin|
|cell killing|
|regulation of organ growth|
|negative regulation of ion transmembrane transport|
|hormone activity|
|regulation of striated muscle cell differentiation|
|cellular transition metal ion homeostasis|
|negative regulation of transmembrane transport|
|liver development|
|response to ethanol|
|hepaticobiliary system development|
|transition metal ion homeostasis|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of ion transport|
|response to ionizing radiation|
|regulation of muscle cell differentiation|
|modification of morphology or physiology of other organism|
|regeneration|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|cellular response to radiation|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|response to starvation|
|cellular response to acid chemical|
|response to nutrient|
|cellular response to biotic stimulus|
|response to alcohol|
|regulation of muscle system process|
|cellular response to tumor necrosis factor|
|positive regulation of growth|
|response to tumor necrosis factor|
|aging|
|response to antibiotic|
|response to lipopolysaccharide|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|regulation of developmental growth|
|defense response to bacterium|
|regulation of cation transmembrane transport|
|response to acid chemical|
|response to metal ion|
|regulation of metal ion transport|
|gland development|
|regulation of cell growth|
|response to radiation|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|inflammatory response|
|response to nutrient levels|
|response to toxic substance|
|cellular response to lipid|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of growth|
|response to bacterium|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|interspecies interaction between organisms|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|response to organic cyclic compound|
|regulation of cell development|
|defense response to other organism|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|response to cytokine|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|extracellular space|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 101/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|5/28|
|bone|3/26|
|breast|6/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|9/75|
|lymphocyte|3/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|4/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12459
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HAMP Expression in NALM6 Cells: 2.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>