HAUS8 [The Human Chemical-Genetic Interaction Map Project]

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======= HAUS8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HAUS8
  * **<color #00a2e8>Official Name</color>**: HAUS augmin like complex subunit 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93323|93323]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT25|Q9BT25]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HAUS8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HAUS8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613434|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear microtubule|
|HAUS complex|
|centrosome cycle|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|spindle assembly|
|spindle pole|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|spindle organization|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|cilium assembly|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|molecular function|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.2|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.19|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.13|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.03|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.88|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.87|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.83|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.77|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.75|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.73|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.71|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.7|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.81|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.83|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.568|
|[[:human genes:t:thg1l|THG1L]]|0.559|
|[[:human genes:r:rnmt|RNMT]]|0.553|
|[[:human genes:a:alg1|ALG1]]|0.533|
|[[:human genes:a:alg13|ALG13]]|0.523|
|[[:human genes:g:gmppb|GMPPB]]|0.512|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.506|
|[[:human genes:m:med16|MED16]]|0.501|
|[[:human genes:r:rpe|RPE]]|0.5|
|[[:human genes:t:triap1|TRIAP1]]|0.497|
|[[:human genes:h:hars|HARS]]|0.496|
|[[:human genes:a:atxn10|ATXN10]]|0.496|
|[[:human genes:r:rtcb|RTCB]]|0.493|
|[[:human genes:v:vezt|VEZT]]|0.492|
|[[:human genes:d:dpagt1|DPAGT1]]|0.491|
|[[:human genes:u:uap1|UAP1]]|0.488|
|[[:human genes:o:oraov1|ORAOV1]]|0.488|
|[[:human genes:a:adsl|ADSL]]|0.486|
|[[:human genes:r:rptor|RPTOR]]|0.478|
|[[:human genes:e:exoc4|EXOC4]]|0.478|
|[[:human genes:d:dhps|DHPS]]|0.475|
|[[:human genes:t:tti2|TTI2]]|0.475|
|[[:human genes:s:srp68|SRP68]]|0.474|
|[[:human genes:e:elac2|ELAC2]]|0.474|
|[[:human genes:n:nsmce1|NSMCE1]]|0.472|
|[[:human genes:g:gnb1l|GNB1L]]|0.468|
|[[:human genes:n:nae1|NAE1]]|0.468|
|[[:human genes:a:alg2|ALG2]]|0.468|
|[[:human genes:f:fnta|FNTA]]|0.467|
|[[:human genes:u:uhrf1|UHRF1]]|0.467|
|[[:human genes:t:tbca|TBCA]]|0.467|
|[[:human genes:o:osgep|OSGEP]]|0.465|
|[[:human genes:w:wdr59|WDR59]]|0.46|
|[[:human genes:t:telo2|TELO2]]|0.459|
|[[:human genes:g:gfpt1|GFPT1]]|0.459|
|[[:human genes:s:srp14|SRP14]]|0.458|
|[[:human genes:u:utp23|UTP23]]|0.457|
|[[:human genes:d:ddx20|DDX20]]|0.457|
|[[:human genes:d:ddx55|DDX55]]|0.455|
|[[:human genes:t:txnl4b|TXNL4B]]|0.455|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.455|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.454|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.453|
|[[:human genes:d:dohh|DOHH]]|0.452|
|[[:human genes:a:alg5|ALG5]]|0.451|
|[[:human genes:t:tgs1|TGS1]]|0.451|
|[[:human genes:t:trmt10a|TRMT10A]]|0.451|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.449|
|[[:human genes:t:tma16|TMA16]]|0.448|
|[[:human genes:e:eef1e1|EEF1E1]]|0.447|
|[[:human genes:n:nars|NARS]]|0.446|
|[[:human genes:p:pam16|PAM16]]|0.446|
|[[:human genes:c:chchd4|CHCHD4]]|0.441|
|[[:human genes:p:pelo|PELO]]|0.44|
|[[:human genes:t:taz|TAZ]]|0.44|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.438|
|[[:human genes:e:eny2|ENY2]]|0.436|
|[[:human genes:t:tsen54|TSEN54]]|0.436|
|[[:human genes:d:dr1|DR1]]|0.436|
|[[:human genes:a:aars|AARS]]|0.435|
|[[:human genes:t:thoc3|THOC3]]|0.435|
|[[:human genes:r:rpp21|RPP21]]|0.433|
|[[:human genes:g:gemin8|GEMIN8]]|0.432|
|[[:human genes:c:c17orf89|C17orf89]]|0.432|
|[[:human genes:u:urm1|URM1]]|0.432|
|[[:human genes:t:ten1|TEN1]]|0.432|
|[[:human genes:c:cbfb|CBFB]]|0.431|
|[[:human genes:h:hspd1|HSPD1]]|0.431|
|[[:human genes:c:cct7|CCT7]]|0.43|
|[[:human genes:g:gemin5|GEMIN5]]|0.429|
|[[:human genes:z:znf259|ZNF259]]|0.428|
|[[:human genes:s:slc25a26|SLC25A26]]|0.427|
|[[:human genes:m:mars|MARS]]|0.426|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.425|
|[[:human genes:l:lsm11|LSM11]]|0.424|
|[[:human genes:p:ppp4c|PPP4C]]|0.423|
|[[:human genes:o:oip5|OIP5]]|0.422|
|[[:human genes:v:vrk1|VRK1]]|0.421|
|[[:human genes:d:dctn5|DCTN5]]|0.419|
|[[:human genes:s:sugt1|SUGT1]]|0.418|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.417|
|[[:human genes:w:wdr24|WDR24]]|0.417|
|[[:human genes:t:trmt5|TRMT5]]|0.414|
|[[:human genes:t:tprkb|TPRKB]]|0.414|
|[[:human genes:r:rbmx2|RBMX2]]|0.41|
|[[:human genes:e:eif3f|EIF3F]]|0.41|
|[[:human genes:d:dhdds|DHDDS]]|0.409|
|[[:human genes:y:yars|YARS]]|0.409|
|[[:human genes:s:sec61g|SEC61G]]|0.407|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.407|
|[[:human genes:e:eprs|EPRS]]|0.406|
|[[:human genes:r:rad1|RAD1]]|0.406|
|[[:human genes:a:atp5j|ATP5J]]|0.405|
|[[:human genes:b:bap1|BAP1]]|0.403|
|[[:human genes:t:tbcd|TBCD]]|0.402|
|[[:human genes:t:trnt1|TRNT1]]|0.4|
|[[:human genes:g:gpn2|GPN2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 82/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|3/28|
|bone|2/26|
|breast|4/33|
|central nervous system|7/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|4/20|
|lung|8/75|
|lymphocyte|3/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3993
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HAUS8 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>