HDAC10 [The Human Chemical-Genetic Interaction Map Project]

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======= HDAC10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC10
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83933|83933]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969S8|Q969S8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608544|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hist deacetyl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetylputrescine deacetylase activity|
|spermidine deacetylation|
|polyamine deacetylation|
|acetylspermidine deacetylase activity|
|positive regulation of mismatch repair|
|regulation of mismatch repair|
|peptidyl-lysine deacetylation|
|spermidine metabolic process|
|protein deacetylase activity|
|deacetylase activity|
|polyamine metabolic process|
|histone deacetylase activity|
|histone deacetylase complex|
|oligodendrocyte development|
|histone deacetylation|
|protein deacetylation|
|homologous recombination|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|protein deacylation|
|macromolecule deacylation|
|positive regulation of DNA repair|
|amine metabolic process|
|oligodendrocyte differentiation|
|positive regulation of response to DNA damage stimulus|
|glial cell development|
|histone deacetylase binding|
|regulation of DNA repair|
|macroautophagy|
|glial cell differentiation|
|ammonium ion metabolic process|
|positive regulation of DNA metabolic process|
|gliogenesis|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|autophagy|
|process utilizing autophagic mechanism|
|peptidyl-lysine modification|
|enzyme binding|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|DNA repair|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|central nervous system development|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|neurogenesis|
|cell development|
|cellular response to stress|
|negative regulation of gene expression|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.74|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.72|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5574
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC10 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>