HDAC9 [The Human Chemical-Genetic Interaction Map Project]

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======= HDAC9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC9
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9734|9734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKV0|Q9UKV0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606543|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HDAC4 Gln|
|Hist deacetyl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase activity (H4-K16 specific)|
|histone H4-K16 deacetylation|
|negative regulation of lipoprotein lipase activity|
|peptidyl-lysine deacetylation|
|NAD-dependent histone deacetylase activity (H3-K14 specific)|
|protein deacetylase activity|
|regulation of skeletal muscle fiber development|
|histone H4 deacetylation|
|negative regulation of lipase activity|
|histone H3 deacetylation|
|positive regulation of cell migration involved in sprouting angiogenesis|
|regulation of lipoprotein lipase activity|
|histone deacetylase activity|
|response to amphetamine|
|histone deacetylase complex|
|regulation of cell migration involved in sprouting angiogenesis|
|repressing transcription factor binding|
|positive regulation of sprouting angiogenesis|
|histone methyltransferase complex|
|response to amine|
|regulation of skeletal muscle tissue development|
|histone deacetylation|
|protein deacetylation|
|response to bronchodilator|
|protein kinase C binding|
|positive regulation of blood vessel endothelial cell migration|
|regulation of myotube differentiation|
|protein deacylation|
|macromolecule deacylation|
|negative regulation of cytokine secretion|
|regulation of sprouting angiogenesis|
|cholesterol homeostasis|
|sterol homeostasis|
|regulation of blood vessel endothelial cell migration|
|regulation of lipase activity|
|positive regulation of endothelial cell migration|
|regulation of striated muscle cell differentiation|
|B cell differentiation|
|histone deacetylase binding|
|negative regulation of protein secretion|
|regulation of striated muscle tissue development|
|lipid homeostasis|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of peptide secretion|
|positive regulation of epithelial cell migration|
|regulation of muscle cell differentiation|
|B cell activation|
|regulation of endothelial cell migration|
|cellular response to insulin stimulus|
|positive regulation of angiogenesis|
|negative regulation of protein transport|
|positive regulation of vasculature development|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|transcription factor complex|
|regulation of epithelial cell migration|
|response to insulin|
|negative regulation of secretion|
|lymphocyte differentiation|
|transcription corepressor activity|
|cellular response to peptide hormone stimulus|
|negative regulation of cytokine production|
|regulation of angiogenesis|
|response to xenobiotic stimulus|
|peptidyl-lysine modification|
|regulation of vasculature development|
|cellular response to peptide|
|leukocyte differentiation|
|transcription factor binding|
|histone modification|
|covalent chromatin modification|
|lymphocyte activation|
|response to peptide hormone|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|response to peptide|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|response to toxic substance|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|hemopoiesis|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|cellular response to nitrogen compound|
|regulation of cytokine production|
|chromatin organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cell motility|
|leukocyte activation|
|regulation of cell development|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell activation|
|response to nitrogen compound|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|neurogenesis|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.83|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.85|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.93|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.09|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.21|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17240
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC9 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>