HDGF [The Human Chemical-Genetic Interaction Map Project]

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======= HDGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDGF
  * **<color #00a2e8>Official Name</color>**: heparin binding growth factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3068|3068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51858|P51858]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600339|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. {ECO:0000269|PubMed:17974029}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PWWP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription corepressor binding|
|response to interleukin-7|
|cellular response to interleukin-7|
|IRE1-mediated unfolded protein response|
|transcriptional repressor complex|
|nucleotide binding|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|growth factor activity|
|heparin binding|
|response to topologically incorrect protein|
|transcription corepressor activity|
|response to endoplasmic reticulum stress|
|collagen-containing extracellular matrix|
|negative regulation of transcription by RNA polymerase II|
|cellular response to cytokine stimulus|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|extracellular space|
|cellular response to stress|
|negative regulation of gene expression|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.77|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.71|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.71|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.8|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.9|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.05|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDGF Expression in NALM6 Cells: 9.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>