HES1 [The Human Chemical-Genetic Interaction Map Project]

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======= HES1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HES1
  * **<color #00a2e8>Official Name</color>**: hes family bHLH transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3280|3280]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14469|Q14469]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HES1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HES1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139605|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hairy orange|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of stomach neuroendocrine cell differentiation|
|regulation of pancreatic A cell differentiation|
|regulation of cell fate determination|
|negative regulation of pancreatic A cell differentiation|
|negative regulation of stomach neuroendocrine cell differentiation|
|N-box binding|
|negative regulation of cell fate determination|
|positive regulation of mitotic cell cycle, embryonic|
|kidney interstitial fibroblast differentiation|
|cell-cell signaling involved in cell fate commitment|
|renal interstitial fibroblast development|
|lateral inhibition|
|trochlear nerve development|
|negative regulation of lymphoid progenitor cell differentiation|
|negative regulation of forebrain neuron differentiation|
|negative regulation of pro-B cell differentiation|
|regulation of timing of neuron differentiation|
|common bile duct development|
|midbrain-hindbrain boundary morphogenesis|
|ascending aorta morphogenesis|
|regulation of mitotic cell cycle, embryonic|
|negative regulation of inner ear auditory receptor cell differentiation|
|negative regulation of inner ear receptor cell differentiation|
|negative regulation of mechanoreceptor differentiation|
|oculomotor nerve development|
|regulation of forebrain neuron differentiation|
|inhibition of neuroepithelial cell differentiation|
|comma-shaped body morphogenesis|
|ascending aorta development|
|cardiac neural crest cell development involved in outflow tract morphogenesis|
|forebrain radial glial cell differentiation|
|regulation of pro-B cell differentiation|
|S-shaped body morphogenesis|
|negative regulation of hematopoietic progenitor cell differentiation|
|metanephric nephron tubule morphogenesis|
|cardiac neural crest cell differentiation involved in heart development|
|regulation of inner ear auditory receptor cell differentiation|
|regulation of mechanoreceptor differentiation|
|pharyngeal arch artery morphogenesis|
|regulation of inner ear receptor cell differentiation|
|regulation of lymphoid progenitor cell differentiation|
|cardiac neural crest cell development involved in heart development|
|regulation of secondary heart field cardioblast proliferation|
|vascular smooth muscle cell development|
|midbrain-hindbrain boundary development|
|regulation of cardioblast proliferation|
|metanephric tubule morphogenesis|
|rostrocaudal neural tube patterning|
|radial glial cell differentiation|
|positive regulation of astrocyte differentiation|
|regulation of timing of cell differentiation|
|adenohypophysis development|
|negative regulation of oligodendrocyte differentiation|
|negative regulation of cell fate commitment|
|vascular smooth muscle cell differentiation|
|negative regulation of glial cell proliferation|
|negative regulation of epidermal cell differentiation|
|regulation of development, heterochronic|
|metanephric nephron tubule development|
|metanephric nephron epithelium development|
|regulation of cell proliferation involved in heart morphogenesis|
|preganglionic parasympathetic fiber development|
|metanephric tubule development|
|glomerulus vasculature development|
|negative regulation of epidermis development|
|labyrinthine layer blood vessel development|
|parasympathetic nervous system development|
|renal system vasculature development|
|kidney vasculature development|
|metanephric nephron morphogenesis|
|metanephric epithelium development|
|negative regulation of stem cell differentiation|
|neuronal stem cell population maintenance|
|negative regulation of glial cell differentiation|
|pharyngeal system development|
|regulation of astrocyte differentiation|
|metanephros morphogenesis|
|regulation of cell fate commitment|
|inner ear receptor cell stereocilium organization|
|aorta morphogenesis|
|placenta blood vessel development|
|regulation of glial cell proliferation|
|establishment of epithelial cell polarity|
|metanephric nephron development|
|positive regulation of BMP signaling pathway|
|smooth muscle cell differentiation|
|neural tube patterning|
|regulation of animal organ formation|
|positive regulation of embryonic development|
|regulation of oligodendrocyte differentiation|
|regulation of heart morphogenesis|
|negative regulation of gliogenesis|
|cell differentiation involved in kidney development|
|hindbrain morphogenesis|
|ventricular septum morphogenesis|
|negative regulation of epithelial cell differentiation|
|inner ear receptor cell development|
|pituitary gland development|
|positive regulation of glial cell differentiation|
|autonomic nervous system development|
|thymus development|
|labyrinthine layer development|
|E-box binding|
|glomerulus development|
|cochlea development|
|aorta development|
|cranial nerve development|
|positive regulation of Notch signaling pathway|
|inner ear receptor cell differentiation|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|positive regulation of DNA binding|
|mechanoreceptor differentiation|
|regulation of epidermal cell differentiation|
|artery morphogenesis|
|nephron tubule morphogenesis|
|somatic stem cell population maintenance|
|nephron epithelium morphogenesis|
|forebrain generation of neurons|
|embryonic heart tube morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|pancreas development|
|smoothened signaling pathway|
|ventricular septum development|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|diencephalon development|
|embryonic heart tube development|
|nephron tubule development|
|nerve development|
|regulation of tyrosine phosphorylation of STAT protein|
|neural crest cell development|
|renal tubule development|
|metanephros development|
|stem cell development|
|mesenchymal cell development|
|kidney morphogenesis|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of epidermis development|
|artery development|
|ureteric bud development|
|midbrain development|
|regulation of hematopoietic progenitor cell differentiation|
|mesonephric epithelium development|
|embryonic placenta development|
|mesonephric tubule development|
|regulation of BMP signaling pathway|
|positive regulation of receptor signaling pathway via STAT|
|neural crest cell differentiation|
|mesonephros development|
|positive regulation of T cell proliferation|
|nephron epithelium development|
|chaperone binding|
|regulation of Notch signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cardiac septum development|
|histone deacetylase binding|
|regulation of gliogenesis|
|cardiocyte differentiation|
|establishment of cell polarity|
|regulation of stem cell differentiation|
|endocrine system development|
|regulation of fat cell differentiation|
|nephron development|
|liver development|
|Notch signaling pathway|
|regulation of DNA binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of embryonic development|
|hepaticobiliary system development|
|kidney epithelium development|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of receptor signaling pathway via STAT|
|stem cell population maintenance|
|negative regulation of hemopoiesis|
|maintenance of cell number|
|positive regulation of leukocyte proliferation|
|regulation of epithelial cell differentiation|
|muscle cell development|
|hindbrain development|
|positive regulation of mitotic cell cycle|
|placenta development|
|regulation of T cell proliferation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|cell maturation|
|neural tube development|
|lung development|
|glial cell differentiation|
|cardiac chamber development|
|respiratory tube development|
|positive regulation of binding|
|positive regulation of peptidyl-tyrosine phosphorylation|
|inner ear development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|gliogenesis|
|positive regulation of leukocyte cell-cell adhesion|
|anterior/posterior pattern specification|
|mesenchyme development|
|ear development|
|regulation of leukocyte proliferation|
|negative regulation of neuron differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|developmental maturation|
|muscle cell differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|telencephalon development|
|regulation of animal organ morphogenesis|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of T cell activation|
|urogenital system development|
|regionalization|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|positive regulation of lymphocyte activation|
|in utero embryonic development|
|regulation of binding|
|positive regulation of cell cycle|
|forebrain development|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|gland development|
|positive regulation of cell activation|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|muscle structure development|
|blood vessel development|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|regulation of cell activation|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15470
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HES1 Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>