HES5 [The Human Chemical-Genetic Interaction Map Project]

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======= HES5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HES5
  * **<color #00a2e8>Official Name</color>**: hes family bHLH transcription factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388585|388585]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TA89|Q5TA89]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HES5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HES5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607348|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hairy orange|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lymphoid progenitor cell differentiation|
|negative regulation of pro-B cell differentiation|
|negative regulation of forebrain neuron differentiation|
|negative regulation of inner ear auditory receptor cell differentiation|
|specification of loop of Henle identity|
|negative regulation of mechanoreceptor differentiation|
|negative regulation of inner ear receptor cell differentiation|
|proximal/distal pattern formation involved in nephron development|
|comma-shaped body morphogenesis|
|regulation of forebrain neuron differentiation|
|inhibition of neuroepithelial cell differentiation|
|specification of nephron tubule identity|
|regulation of pro-B cell differentiation|
|forebrain radial glial cell differentiation|
|S-shaped body morphogenesis|
|negative regulation of hematopoietic progenitor cell differentiation|
|regulation of mechanoreceptor differentiation|
|regulation of lymphoid progenitor cell differentiation|
|regulation of inner ear auditory receptor cell differentiation|
|metanephric nephron tubule morphogenesis|
|regulation of inner ear receptor cell differentiation|
|renal system pattern specification|
|pattern specification involved in kidney development|
|loop of Henle development|
|metanephric tubule morphogenesis|
|radial glial cell differentiation|
|negative regulation of astrocyte differentiation|
|negative regulation of oligodendrocyte differentiation|
|regulation of timing of cell differentiation|
|negative regulation of epidermal cell differentiation|
|glial cell fate commitment|
|regulation of development, heterochronic|
|metanephric nephron tubule development|
|segment specification|
|metanephric nephron epithelium development|
|nephron tubule formation|
|metanephric tubule development|
|negative regulation of epidermis development|
|metanephric nephron morphogenesis|
|axon ensheathment in central nervous system|
|central nervous system myelination|
|negative regulation of stem cell differentiation|
|metanephric epithelium development|
|neuronal stem cell population maintenance|
|negative regulation of glial cell differentiation|
|regulation of astrocyte differentiation|
|metanephros morphogenesis|
|inner ear receptor cell stereocilium organization|
|metanephric nephron development|
|proximal/distal pattern formation|
|establishment of epithelial cell polarity|
|positive regulation of BMP signaling pathway|
|regulation of oligodendrocyte differentiation|
|negative regulation of epithelial cell differentiation|
|negative regulation of gliogenesis|
|inner ear receptor cell development|
|oligodendrocyte development|
|regulation of myelination|
|positive regulation of Notch signaling pathway|
|inner ear receptor cell differentiation|
|astrocyte differentiation|
|mechanoreceptor differentiation|
|regulation of epidermal cell differentiation|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|forebrain generation of neurons|
|nephron morphogenesis|
|positive regulation of tyrosine phosphorylation of STAT protein|
|renal tubule morphogenesis|
|regulation of glial cell differentiation|
|oligodendrocyte differentiation|
|smoothened signaling pathway|
|nephron tubule development|
|regulation of tyrosine phosphorylation of STAT protein|
|renal tubule development|
|chondrocyte differentiation|
|metanephros development|
|kidney morphogenesis|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of epidermis development|
|positive regulation of smooth muscle cell proliferation|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of BMP signaling pathway|
|positive regulation of receptor signaling pathway via STAT|
|segmentation|
|nephron epithelium development|
|regulation of Notch signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|regulation of gliogenesis|
|regulation of stem cell differentiation|
|establishment of cell polarity|
|embryonic epithelial tube formation|
|nephron development|
|Notch signaling pathway|
|regulation of embryonic development|
|kidney epithelium development|
|regulation of receptor signaling pathway via JAK-STAT|
|epithelial tube formation|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|stem cell population maintenance|
|negative regulation of hemopoiesis|
|maintenance of cell number|
|regulation of epithelial cell differentiation|
|morphogenesis of embryonic epithelium|
|tube formation|
|cell maturation|
|protein dimerization activity|
|neural tube development|
|glial cell differentiation|
|cartilage development|
|positive regulation of peptidyl-tyrosine phosphorylation|
|inner ear development|
|establishment or maintenance of cell polarity|
|gliogenesis|
|anterior/posterior pattern specification|
|ear development|
|connective tissue development|
|negative regulation of neuron differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|developmental maturation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|regulation of peptidyl-tyrosine phosphorylation|
|telencephalon development|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|negative regulation of neurogenesis|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|camera-type eye development|
|urogenital system development|
|regionalization|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|chromatin binding|
|morphogenesis of an epithelium|
|pattern specification process|
|negative regulation of immune system process|
|cellular component|
|regulation of hemopoiesis|
|skeletal system development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|negative regulation of cell differentiation|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13221
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HES5 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>