HINFP [The Human Chemical-Genetic Interaction Map Project]

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======= HINFP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HINFP
  * **<color #00a2e8>Official Name</color>**: histone H4 transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25988|25988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQA5|Q9BQA5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HINFP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HINFP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607099|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. {ECO:0000269|PubMed:11553631, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14752047, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:18850719}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|myoblast differentiation|
|Cajal body|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|histone binding|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|cell cycle checkpoint|
|transcription regulatory region DNA binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|transcription coactivator activity|
|enzyme binding|
|in utero embryonic development|
|chromatin binding|
|muscle structure development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA repair|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|embryo development|
|cell cycle process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.71|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.74|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.75|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.8|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.97|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.22|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.577|
|[[:human genes:u:uqcrh|UQCRH]]|0.491|
|[[:human genes:a:aqr|AQR]]|0.473|
|[[:human genes:s:slc4a1|SLC4A1]]|0.468|
|[[:human genes:c:chd4|CHD4]]|0.458|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.451|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.451|
|[[:human genes:a:aamp|AAMP]]|0.449|
|[[:human genes:r:rad51|RAD51]]|0.448|
|[[:human genes:l:lrr1|LRR1]]|0.448|
|[[:human genes:p:psmb4|PSMB4]]|0.448|
|[[:human genes:t:tuba8|TUBA8]]|0.446|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.442|
|[[:human genes:c:cactin|CACTIN]]|0.44|
|[[:human genes:r:rpl35|RPL35]]|0.44|
|[[:human genes:t:tceb3c|TCEB3C]]|0.44|
|[[:human genes:p:pcf11|PCF11]]|0.439|
|[[:human genes:s:supt5h|SUPT5H]]|0.438|
|[[:human genes:p:pola1|POLA1]]|0.436|
|[[:human genes:t:twistnb|TWISTNB]]|0.435|
|[[:human genes:n:nupl1|NUPL1]]|0.434|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.432|
|[[:human genes:p:plk1|PLK1]]|0.431|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.431|
|[[:human genes:p:polr2f|POLR2F]]|0.428|
|[[:human genes:f:fam160a1|FAM160A1]]|0.427|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.425|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.425|
|[[:human genes:r:rpl6|RPL6]]|0.423|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.422|
|[[:human genes:e:exosc8|EXOSC8]]|0.422|
|[[:human genes:m:mt1e|MT1E]]|0.421|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.421|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.42|
|[[:human genes:s:slc6a17|SLC6A17]]|0.419|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:s:sf3a1|SF3A1]]|0.419|
|[[:human genes:c:col2a1|COL2A1]]|0.419|
|[[:human genes:t:ticrr|TICRR]]|0.416|
|[[:human genes:p:prim1|PRIM1]]|0.412|
|[[:human genes:a:ankle1|ANKLE1]]|0.412|
|[[:human genes:s:supt6h|SUPT6H]]|0.411|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.409|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.409|
|[[:human genes:s:sf3a2|SF3A2]]|0.407|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.407|
|[[:human genes:d:ddtl|DDTL]]|0.406|
|[[:human genes:n:npipb5|NPIPB5]]|0.406|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.406|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.405|
|[[:human genes:v:vasn|VASN]]|0.405|
|[[:human genes:p:psmd3|PSMD3]]|0.405|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.404|
|[[:human genes:c:cep192|CEP192]]|0.402|
|[[:human genes:n:nop16|NOP16]]|0.402|
|[[:human genes:t:timeless|TIMELESS]]|0.401|
|[[:human genes:r:rilpl1|RILPL1]]|0.4|
|[[:human genes:c:copa|COPA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 612/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|26/28|
|blood|27/28|
|bone|23/25|
|breast|30/33|
|central nervous system|47/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|20/21|
|liver|15/20|
|lung|61/75|
|lymphocyte|12/14|
|ovary|20/26|
|pancreas|22/24|
|peripheral nervous system|14/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 133
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HINFP Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>