HIST1H1E [The Human Chemical-Genetic Interaction Map Project]

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======= HIST1H1E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H1-4
  * **<color #00a2e8>Official Name</color>**: H1.4 linker histone, cluster member
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3008|3008]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10412|P10412]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H1E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H1E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Linker histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dATP binding|
|histone H3-K27 trimethylation|
|histone H3-K27 methylation|
|AMP binding|
|nuclear nucleosome|
|histone H3-K4 trimethylation|
|nucleosome positioning|
|negative regulation of chromatin silencing|
|nuclear heterochromatin|
|peptidyl-lysine trimethylation|
|nuclear euchromatin|
|negative regulation of gene silencing|
|histone H3-K4 methylation|
|ADP binding|
|regulation of chromatin silencing|
|chromosome condensation|
|nucleosomal DNA binding|
|negative regulation of DNA recombination|
|negative regulation of chromatin organization|
|positive regulation of gene expression, epigenetic|
|chromatin DNA binding|
|histone lysine methylation|
|peptidyl-lysine methylation|
|histone methylation|
|double-stranded DNA binding|
|regulation of DNA recombination|
|nucleosome assembly|
|negative regulation of DNA metabolic process|
|regulation of gene silencing|
|protein alkylation|
|negative regulation of chromosome organization|
|protein methylation|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|macromolecule methylation|
|DNA conformation change|
|methylation|
|peptidyl-lysine modification|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|GTP binding|
|chromatin organization|
|negative regulation of cellular component organization|
|calcium ion binding|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.74|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.74|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.76|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.79|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.86|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hist1h1b|HIST1H1B]]|0.46|
|[[:human genes:h:hist1h1d|HIST1H1D]]|0.427|
|[[:human genes:c:cramp1l|CRAMP1L]]|0.42|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15316
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H1E Expression in NALM6 Cells: 1.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>