HIST1H2BI [The Human Chemical-Genetic Interaction Map Project]

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======= HIST1H2BI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H2BC10
  * **<color #00a2e8>Official Name</color>**: H2B clustered histone 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8346|8346]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62807|P62807]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H2BI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H2BI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602807|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
|CBFD NFYB HMF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.7|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.7|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.73|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.73|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.75|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.76|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.76|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2204
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H2BI Expression in NALM6 Cells: -1.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>