HIST1H2BK [The Human Chemical-Genetic Interaction Map Project]

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======= HIST1H2BK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H2BC12
  * **<color #00a2e8>Official Name</color>**: H2B clustered histone 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85236|85236]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60814|O60814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H2BK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H2BK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBFD NFYB HMF|
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|innate immune response in mucosa|
|mucosal immune response|
|organ or tissue specific immune response|
|antibacterial humoral response|
|killing of cells of other organism|
|disruption of cells of other organism|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|nucleosome|
|defense response to Gram-negative bacterium|
|cell killing|
|defense response to Gram-positive bacterium|
|antimicrobial humoral response|
|nucleosome assembly|
|chromatin assembly|
|chromatin assembly or disassembly|
|modification of morphology or physiology of other organism|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|defense response to bacterium|
|humoral immune response|
|protein heterodimerization activity|
|protein ubiquitination|
|response to bacterium|
|chromatin organization|
|molecular function|
|innate immune response|
|protein modification by small protein conjugation|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|DNA binding|
|protein-containing complex assembly|
|extracellular space|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5a1|ATP5A1]]|0.439|
|[[:human genes:h:h2afz|H2AFZ]]|0.425|
|[[:human genes:a:atp5b|ATP5B]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2803
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H2BK Expression in NALM6 Cells: 0.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>