HJURP [The Human Chemical-Genetic Interaction Map Project]

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======= HJURP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HJURP
  * **<color #00a2e8>Official Name</color>**: Holliday junction recognition protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55355|55355]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NCD3|Q8NCD3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HJURP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HJURP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612667|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HJURP C|
|Scm3|
|HJURP mid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|chromosome, centromeric region|
|ATP-dependent chromatin remodeling|
|condensed chromosome kinetochore|
|nucleosome assembly|
|regulation of DNA binding|
|histone binding|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|chromosome segregation|
|DNA conformation change|
|regulation of binding|
|regulation of protein complex assembly|
|chromatin organization|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of cellular component biogenesis|
|chromosome organization|
|identical protein binding|
|mitochondrion|
|cell cycle|
|DNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.1|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 170/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|5/28|
|bone|4/25|
|breast|8/33|
|central nervous system|18/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|3/15|
|kidney|3/21|
|liver|7/20|
|lung|24/75|
|lymphocyte|3/14|
|ovary|4/26|
|pancreas|8/24|
|peripheral nervous system|7/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 802
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HJURP Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>