HLA-DPA1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= HLA-DPA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HLA-DPA1
  * **<color #00a2e8>Official Name</color>**: major histocompatibility complex, class II, DP alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3113|3113]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20036|P20036]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HLA-DPA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HLA-DPA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MHC II alpha|
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MHC class II receptor activity|
|MHC class II protein complex|
|integral component of lumenal side of endoplasmic reticulum membrane|
|peptide antigen binding|
|clathrin-coated endocytic vesicle membrane|
|transport vesicle membrane|
|ER to Golgi transport vesicle membrane|
|positive regulation of interferon-gamma production|
|endocytic vesicle membrane|
|interferon-gamma-mediated signaling pathway|
|trans-Golgi network membrane|
|positive regulation of T cell proliferation|
|regulation of interferon-gamma production|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of T cell proliferation|
|cellular response to interferon-gamma|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|response to interferon-gamma|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|endosome membrane|
|positive regulation of leukocyte cell-cell adhesion|
|antigen processing and presentation|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|lysosomal membrane|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of lymphocyte activation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|Golgi membrane|
|activation of immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|innate immune response|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|defense response to other organism|
|cellular response to cytokine stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14074
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HLA-DPA1 Expression in NALM6 Cells: 8.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>