HMGB4 [The Human Chemical-Genetic Interaction Map Project]

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======= HMGB4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMGB4
  * **<color #00a2e8>Official Name</color>**: high mobility group box 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=127540|127540]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WW32|Q8WW32]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMGB4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMGB4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of interferon-alpha secretion|
|positive regulation of interferon-alpha secretion|
|DNA binding, bending|
|positive regulation of interferon-alpha production|
|regulation of interferon-alpha production|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 secretion|
|regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|positive regulation of interleukin-1 production|
|positive regulation of NIK/NF-kappaB signaling|
|positive regulation of type I interferon production|
|regulation of interleukin-1 beta production|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of interleukin-1 production|
|positive regulation of interleukin-6 production|
|regulation of NIK/NF-kappaB signaling|
|positive regulation of autophagy|
|regulation of type I interferon production|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|chromatin remodeling|
|regulation of signaling receptor activity|
|regulation of cytokine secretion|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|DNA recombination|
|nuclear chromatin|
|activation of innate immune response|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|regulation of autophagy|
|transcription factor binding|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of cytokine production|
|chromatin organization|
|regulation of protein transport|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of secretion|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|cell migration|
|positive regulation of transport|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|chromosome organization|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|locomotion|
|regulation of protein phosphorylation|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-2.1|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMGB4 Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>