HMGCS1 [The Human Chemical-Genetic Interaction Map Project]

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======= HMGCS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMGCS1
  * **<color #00a2e8>Official Name</color>**: 3-hydroxy-3-methylglutaryl-CoA synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3157|3157]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01581|Q01581]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMGCS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMGCS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142940|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG CoA synt C|
|HMG CoA synt N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to low light intensity stimulus|
|response to tellurium ion|
|isoprenoid biosynthetic process via mevalonate|
|hydroxymethylglutaryl-CoA synthase activity|
|farnesyl diphosphate biosynthetic process, mevalonate pathway|
|farnesyl diphosphate biosynthetic process|
|farnesyl diphosphate metabolic process|
|organic acid binding|
|cellular response to follicle-stimulating hormone stimulus|
|response to vitamin E|
|response to light intensity|
|isomerase activity|
|terpenoid biosynthetic process|
|response to follicle-stimulating hormone|
|cellular response to cholesterol|
|cellular response to gonadotropin stimulus|
|cellular response to low-density lipoprotein particle stimulus|
|cellular response to sterol|
|response to cholesterol|
|response to lipoprotein particle|
|isoprenoid biosynthetic process|
|response to gonadotropin|
|cellular response to lipoprotein particle stimulus|
|response to sterol|
|acetyl-CoA metabolic process|
|cholesterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of sterol biosynthetic process|
|sterol biosynthetic process|
|regulation of cholesterol metabolic process|
|drug binding|
|regulation of alcohol biosynthetic process|
|cellular response to alcohol|
|response to vitamin|
|regulation of steroid biosynthetic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|terpenoid metabolic process|
|liver development|
|steroid biosynthetic process|
|hepaticobiliary system development|
|secondary alcohol metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|male gonad development|
|sterol metabolic process|
|development of primary male sexual characteristics|
|isoprenoid metabolic process|
|response to purine-containing compound|
|male sex differentiation|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|gonad development|
|response to nutrient|
|development of primary sexual characteristics|
|response to alcohol|
|phospholipid biosynthetic process|
|coenzyme metabolic process|
|steroid metabolic process|
|sex differentiation|
|response to light stimulus|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|phospholipid metabolic process|
|regulation of lipid metabolic process|
|gland development|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|cofactor metabolic process|
|response to radiation|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|brain development|
|head development|
|cellular amide metabolic process|
|response to lipid|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to hormone|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|central nervous system development|
|response to organonitrogen compound|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to abiotic stimulus|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.24|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.21|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.02|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.96|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.92|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.71|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.682|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 487/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|26/28|
|bone|14/26|
|breast|24/33|
|central nervous system|22/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|17/21|
|liver|13/20|
|lung|45/75|
|lymphocyte|12/16|
|ovary|15/26|
|pancreas|15/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|15/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 687
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMGCS1 Expression in NALM6 Cells: 7.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>