HMGXB3 [The Human Chemical-Genetic Interaction Map Project]

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======= HMGXB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMGXB3
  * **<color #00a2e8>Official Name</color>**: HMG-box containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22993|22993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12766|Q12766]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMGXB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMGXB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619800|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular component|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.7|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.85|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.88|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.89|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.91|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.96|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.96|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.04|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.11|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.2|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.25|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.3|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.33|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.43|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.5|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.63|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl45|MRPL45]]|0.571|
|[[:human genes:n:ndufc2|NDUFC2]]|0.56|
|[[:human genes:n:ndufa1|NDUFA1]]|0.556|
|[[:human genes:c:chchd1|CHCHD1]]|0.542|
|[[:human genes:r:rpusd3|RPUSD3]]|0.539|
|[[:human genes:g:gfm1|GFM1]]|0.538|
|[[:human genes:f:ftsj2|FTSJ2]]|0.537|
|[[:human genes:n:nars2|NARS2]]|0.534|
|[[:human genes:g:grsf1|GRSF1]]|0.531|
|[[:human genes:r:rpusd4|RPUSD4]]|0.527|
|[[:human genes:n:ndufa3|NDUFA3]]|0.527|
|[[:human genes:f:fastkd2|FASTKD2]]|0.527|
|[[:human genes:a:acad9|ACAD9]]|0.522|
|[[:human genes:e:eral1|ERAL1]]|0.52|
|[[:human genes:n:ndufs2|NDUFS2]]|0.519|
|[[:human genes:n:ndufb11|NDUFB11]]|0.518|
|[[:human genes:m:mcat|MCAT]]|0.516|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.516|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.507|
|[[:human genes:l:lars2|LARS2]]|0.506|
|[[:human genes:p:pars2|PARS2]]|0.504|
|[[:human genes:q:qrsl1|QRSL1]]|0.504|
|[[:human genes:s:ssbp1|SSBP1]]|0.503|
|[[:human genes:n:ndufa11|NDUFA11]]|0.499|
|[[:human genes:e:ecsit|ECSIT]]|0.498|
|[[:human genes:m:mrps35|MRPS35]]|0.496|
|[[:human genes:t:tfb1m|TFB1M]]|0.496|
|[[:human genes:m:mrps16|MRPS16]]|0.495|
|[[:human genes:w:wbscr16|WBSCR16]]|0.494|
|[[:human genes:m:mrps21|MRPS21]]|0.493|
|[[:human genes:g:gfm2|GFM2]]|0.491|
|[[:human genes:n:ndufb10|NDUFB10]]|0.491|
|[[:human genes:m:mipep|MIPEP]]|0.49|
|[[:human genes:c:cars2|CARS2]]|0.489|
|[[:human genes:n:ndufb5|NDUFB5]]|0.487|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.485|
|[[:human genes:n:nubpl|NUBPL]]|0.484|
|[[:human genes:m:mrpl12|MRPL12]]|0.483|
|[[:human genes:m:malsu1|MALSU1]]|0.483|
|[[:human genes:m:mtg1|MTG1]]|0.483|
|[[:human genes:g:glrx5|GLRX5]]|0.481|
|[[:human genes:m:mettl17|METTL17]]|0.479|
|[[:human genes:m:mrps6|MRPS6]]|0.478|
|[[:human genes:n:ndufb7|NDUFB7]]|0.477|
|[[:human genes:m:mrpl23|MRPL23]]|0.477|
|[[:human genes:p:ptcd3|PTCD3]]|0.477|
|[[:human genes:n:ndufb6|NDUFB6]]|0.477|
|[[:human genes:m:mrps34|MRPS34]]|0.476|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.476|
|[[:human genes:m:mtif2|MTIF2]]|0.475|
|[[:human genes:n:nsun4|NSUN4]]|0.475|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.473|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.471|
|[[:human genes:r:rars2|RARS2]]|0.47|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.469|
|[[:human genes:s:sfxn4|SFXN4]]|0.468|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.468|
|[[:human genes:m:mrpl47|MRPL47]]|0.467|
|[[:human genes:p:pet117|PET117]]|0.467|
|[[:human genes:m:mrpl49|MRPL49]]|0.467|
|[[:human genes:m:mtg2|MTG2]]|0.464|
|[[:human genes:c:c12orf65|C12orf65]]|0.462|
|[[:human genes:n:ndufs7|NDUFS7]]|0.462|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.461|
|[[:human genes:i:iba57|IBA57]]|0.459|
|[[:human genes:n:ndufb9|NDUFB9]]|0.458|
|[[:human genes:r:rbfa|RBFA]]|0.457|
|[[:human genes:m:mrpl43|MRPL43]]|0.457|
|[[:human genes:m:mrpl53|MRPL53]]|0.457|
|[[:human genes:n:ndufa2|NDUFA2]]|0.456|
|[[:human genes:d:ddx28|DDX28]]|0.456|
|[[:human genes:t:tefm|TEFM]]|0.456|
|[[:human genes:m:mrps7|MRPS7]]|0.455|
|[[:human genes:m:mrpl21|MRPL21]]|0.455|
|[[:human genes:m:mto1|MTO1]]|0.455|
|[[:human genes:t:tars2|TARS2]]|0.454|
|[[:human genes:m:mrps5|MRPS5]]|0.454|
|[[:human genes:m:mrps25|MRPS25]]|0.454|
|[[:human genes:c:coq2|COQ2]]|0.451|
|[[:human genes:m:mrpl44|MRPL44]]|0.451|
|[[:human genes:p:pet112|PET112]]|0.45|
|[[:human genes:y:yars2|YARS2]]|0.448|
|[[:human genes:m:mrps22|MRPS22]]|0.448|
|[[:human genes:n:ndufb2|NDUFB2]]|0.444|
|[[:human genes:m:mrpl3|MRPL3]]|0.443|
|[[:human genes:p:polg2|POLG2]]|0.443|
|[[:human genes:n:ndufa8|NDUFA8]]|0.443|
|[[:human genes:s:selrc1|SELRC1]]|0.442|
|[[:human genes:a:atp5sl|ATP5SL]]|0.442|
|[[:human genes:i:ict1|ICT1]]|0.441|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.439|
|[[:human genes:c:c10orf2|C10orf2]]|0.437|
|[[:human genes:m:mrp63|MRP63]]|0.436|
|[[:human genes:m:mrps9|MRPS9]]|0.436|
|[[:human genes:m:mrps26|MRPS26]]|0.433|
|[[:human genes:p:polg|POLG]]|0.432|
|[[:human genes:c:coa3|COA3]]|0.429|
|[[:human genes:a:aars2|AARS2]]|0.429|
|[[:human genes:f:fastkd5|FASTKD5]]|0.428|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.427|
|[[:human genes:n:ndufc1|NDUFC1]]|0.425|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.423|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.421|
|[[:human genes:m:mrps27|MRPS27]]|0.42|
|[[:human genes:d:dars2|DARS2]]|0.418|
|[[:human genes:m:mrps14|MRPS14]]|0.418|
|[[:human genes:g:gatc|GATC]]|0.417|
|[[:human genes:m:mrpl17|MRPL17]]|0.416|
|[[:human genes:m:mrps18b|MRPS18B]]|0.416|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.415|
|[[:human genes:p:ptcd1|PTCD1]]|0.414|
|[[:human genes:n:ndufb3|NDUFB3]]|0.413|
|[[:human genes:m:mrpl48|MRPL48]]|0.413|
|[[:human genes:n:ndufv1|NDUFV1]]|0.412|
|[[:human genes:c:clpp|CLPP]]|0.412|
|[[:human genes:d:dap3|DAP3]]|0.411|
|[[:human genes:n:ndufa10|NDUFA10]]|0.407|
|[[:human genes:r:rmnd1|RMND1]]|0.406|
|[[:human genes:p:pde12|PDE12]]|0.405|
|[[:human genes:m:mterfd1|MTERFD1]]|0.405|
|[[:human genes:t:trub2|TRUB2]]|0.404|
|[[:human genes:c:coa6|COA6]]|0.404|
|[[:human genes:m:mrps12|MRPS12]]|0.403|
|[[:human genes:m:mterfd2|MTERFD2]]|0.403|
|[[:human genes:t:tmem261|TMEM261]]|0.402|
|[[:human genes:v:vars2|VARS2]]|0.402|
|[[:human genes:w:wars2|WARS2]]|0.401|
|[[:human genes:m:mrpl55|MRPL55]]|0.401|
|[[:human genes:m:mrpl18|MRPL18]]|0.401|
|[[:human genes:m:mrpl28|MRPL28]]|0.4|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 463
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMGXB3 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>