HNF4A [The Human Chemical-Genetic Interaction Map Project]

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======= HNF4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNF4A
  * **<color #00a2e8>Official Name</color>**: hepatocyte nuclear factor 4 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3172|3172]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41235|P41235]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNF4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNF4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600281|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ornithine metabolic process|
|phospholipid homeostasis|
|hepatocyte differentiation|
|type B pancreatic cell development|
|glandular epithelial cell development|
|type B pancreatic cell differentiation|
|enteroendocrine cell differentiation|
|signal transduction involved in regulation of gene expression|
|fatty acid binding|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|regulation of gastrulation|
|endocrine pancreas development|
|glandular epithelial cell differentiation|
|columnar/cuboidal epithelial cell development|
|steroid hormone receptor activity|
|RNA polymerase II activating transcription factor binding|
|SMAD protein signal transduction|
|anion homeostasis|
|pancreas development|
|cholesterol homeostasis|
|sterol homeostasis|
|columnar/cuboidal epithelial cell differentiation|
|regulation of circadian rhythm|
|steroid hormone mediated signaling pathway|
|endocrine system development|
|liver development|
|hepaticobiliary system development|
|regulation of embryonic development|
|xenobiotic metabolic process|
|lipid homeostasis|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|hormone-mediated signaling pathway|
|response to carbohydrate|
|transcription initiation from RNA polymerase II promoter|
|regulation of insulin secretion|
|negative regulation of cell growth|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|epithelial cell development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of peptide hormone secretion|
|alpha-amino acid metabolic process|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|negative regulation of growth|
|sex differentiation|
|regulation of hormone secretion|
|rhythmic process|
|blood coagulation|
|coagulation|
|hemostasis|
|response to xenobiotic stimulus|
|cellular amino acid metabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to steroid hormone|
|signaling receptor binding|
|regulation of lipid metabolic process|
|gland development|
|regulation of cell growth|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of protein secretion|
|wound healing|
|transcription by RNA polymerase II|
|regulation of peptide secretion|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|response to wounding|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|zinc ion binding|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10544
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNF4A Expression in NALM6 Cells: 1.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>