HORMAD1 [The Human Chemical-Genetic Interaction Map Project]

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======= HORMAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HORMAD1
  * **<color #00a2e8>Official Name</color>**: HORMA domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84072|84072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86X24|Q86X24]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HORMAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HORMAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609824|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HORMA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of homologous chromosome segregation|
|meiotic recombination checkpoint|
|meiotic cell cycle checkpoint|
|meiotic DNA double-strand break formation|
|regulation of meiosis I|
|meiotic sister chromatid segregation|
|meiotic sister chromatid cohesion|
|meiosis II|
|meiosis II cell cycle process|
|negative regulation of meiotic nuclear division|
|negative regulation of meiotic cell cycle|
|synaptonemal complex assembly|
|synaptonemal complex organization|
|synaptonemal complex|
|regulation of meiotic nuclear division|
|synapsis|
|negative regulation of nuclear division|
|regulation of meiotic cell cycle|
|sister chromatid cohesion|
|negative regulation of reproductive process|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|oogenesis|
|meiotic chromosome segregation|
|blastocyst development|
|regulation of chromosome segregation|
|meiosis I|
|meiosis I cell cycle process|
|chromosome|
|female gamete generation|
|sister chromatid segregation|
|meiotic nuclear division|
|regulation of reproductive process|
|meiotic cell cycle process|
|regulation of nuclear division|
|cell cycle checkpoint|
|nuclear chromosome segregation|
|meiotic cell cycle|
|germ cell development|
|chromosome segregation|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|organelle fission|
|negative regulation of cell cycle process|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of organelle organization|
|in utero embryonic development|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|gamete generation|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|embryo development|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10625
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HORMAD1 Expression in NALM6 Cells: -2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>