HOXA1 [The Human Chemical-Genetic Interaction Map Project]

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======= HOXA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXA1
  * **<color #00a2e8>Official Name</color>**: homeobox A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3198|3198]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49639|P49639]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142955|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|optokinetic behavior|
|abducens nerve morphogenesis|
|abducens nerve formation|
|semicircular canal formation|
|abducens nerve development|
|embryonic neurocranium morphogenesis|
|semicircular canal morphogenesis|
|cranial nerve formation|
|outer ear morphogenesis|
|semicircular canal development|
|cochlea morphogenesis|
|cranial nerve morphogenesis|
|embryonic cranial skeleton morphogenesis|
|cochlea development|
|cranial nerve development|
|visual behavior|
|artery morphogenesis|
|cranial skeletal system development|
|regulation of behavior|
|nerve development|
|artery development|
|embryonic skeletal system morphogenesis|
|inner ear morphogenesis|
|neuromuscular process|
|ear morphogenesis|
|embryonic skeletal system development|
|sensory perception of sound|
|tube formation|
|sensory perception of mechanical stimulus|
|inner ear development|
|ear development|
|skeletal system morphogenesis|
|sensory organ morphogenesis|
|embryonic organ morphogenesis|
|cognition|
|response to light stimulus|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|embryonic organ development|
|response to radiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|blood vessel development|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|sensory organ development|
|embryonic morphogenesis|
|behavior|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|identical protein binding|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|nervous system process|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.22|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.33|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.52|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.68|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.8|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.19|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10725
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXA1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>