HOXA9 [The Human Chemical-Genetic Interaction Map Project]

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======= HOXA9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXA9
  * **<color #00a2e8>Official Name</color>**: homeobox A9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3205|3205]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31269|P31269]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXA9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXA9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142956|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. {ECO:0000269|PubMed:22269951}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hox9 act|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial cell activation|
|definitive hemopoiesis|
|uterus development|
|proximal/distal pattern formation|
|embryonic forelimb morphogenesis|
|forelimb morphogenesis|
|negative regulation of myeloid cell differentiation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|embryonic skeletal system development|
|mammary gland development|
|male gonad development|
|development of primary male sexual characteristics|
|negative regulation of hemopoiesis|
|single fertilization|
|appendage morphogenesis|
|limb morphogenesis|
|male sex differentiation|
|fertilization|
|limb development|
|appendage development|
|transcription factor complex|
|gonad development|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|regulation of myeloid cell differentiation|
|sex differentiation|
|regionalization|
|enzyme binding|
|gland development|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|gamete generation|
|negative regulation of cell differentiation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of developmental process|
|embryo development|
|multi-organism reproductive process|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.42|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.91|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.74|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.74|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.88|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.11|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.37|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.31|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|4.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14876
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXA9 Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>