HPN [The Human Chemical-Genetic Interaction Map Project]

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======= HPN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HPN
  * **<color #00a2e8>Official Name</color>**: hepsin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3249|3249]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05981|P05981]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HPN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HPN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:8346233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
|Hepsin-SRCR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|basement membrane disassembly|
|positive regulation of thyroid hormone generation|
|pilomotor reflex|
|serine-type exopeptidase activity|
|regulation of thyroid hormone generation|
|positive regulation of plasminogen activation|
|positive regulation of hepatocyte proliferation|
|hepatocyte growth factor receptor signaling pathway|
|detection of mechanical stimulus involved in sensory perception of sound|
|regulation of plasminogen activation|
|calcium-activated potassium channel activity|
|regulation of hepatocyte proliferation|
|positive regulation of hormone metabolic process|
|positive regulation by host of viral transcription|
|reflex|
|basement membrane organization|
|positive regulation of protein processing|
|cochlea morphogenesis|
|positive regulation of protein maturation|
|response to thyroid hormone|
|negative regulation of epithelial to mesenchymal transition|
|detection of mechanical stimulus involved in sensory perception|
|regulation of hormone metabolic process|
|positive regulation of viral transcription|
|detection of mechanical stimulus|
|cochlea development|
|serine-type peptidase activity|
|regulation of viral transcription|
|regulation of protein processing|
|regulation of protein maturation|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|peptidase activity|
|positive regulation of animal organ morphogenesis|
|regulation of epithelial to mesenchymal transition|
|inner ear morphogenesis|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|ear morphogenesis|
|detection of external stimulus|
|detection of abiotic stimulus|
|negative regulation of epithelial cell proliferation|
|sensory perception of sound|
|regulation of cell shape|
|modification of morphology or physiology of other organism|
|potassium ion transmembrane transport|
|positive regulation of cell growth|
|serine-type endopeptidase activity|
|sensory perception of mechanical stimulus|
|potassium ion transport|
|cell-cell junction|
|positive regulation of epithelial cell proliferation|
|inner ear development|
|regulation of viral process|
|response to mechanical stimulus|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ear development|
|nuclear membrane|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|embryonic organ morphogenesis|
|apical plasma membrane|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|positive regulation of proteolysis|
|neuronal cell body|
|extracellular structure organization|
|monovalent inorganic cation transport|
|cellular component disassembly|
|regulation of cell growth|
|embryonic organ development|
|regulation of cell morphogenesis|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of hormone levels|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|inorganic cation transmembrane transport|
|embryonic morphogenesis|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of growth|
|negative regulation of cell population proliferation|
|detection of stimulus|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cation transport|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|ion transmembrane transport|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HPN Expression in NALM6 Cells: 0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>