HRH1 [The Human Chemical-Genetic Interaction Map Project]

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======= HRH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HRH1
  * **<color #00a2e8>Official Name</color>**: histamine receptor H1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3269|3269]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35367|P35367]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HRH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HRH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600167|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of inositol trisphosphate biosynthetic process|
|histamine receptor activity|
|regulation of inositol trisphosphate biosynthetic process|
|cellular response to histamine|
|response to histamine|
|positive regulation of inositol phosphate biosynthetic process|
|regulation of inositol phosphate biosynthetic process|
|eosinophil chemotaxis|
|eosinophil migration|
|inositol phosphate-mediated signaling|
|positive regulation of alcohol biosynthetic process|
|positive regulation of vasoconstriction|
|G protein-coupled serotonin receptor activity|
|G protein-coupled serotonin receptor signaling pathway|
|regulation of vascular permeability|
|neurotransmitter receptor activity|
|serotonin receptor signaling pathway|
|visual learning|
|visual behavior|
|regulation of vasoconstriction|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of blood circulation|
|regulation of alcohol biosynthetic process|
|associative learning|
|positive regulation of carbohydrate metabolic process|
|cellular response to dopamine|
|response to dopamine|
|granulocyte chemotaxis|
|signal transduction involved in cellular response to ammonium ion|
|regulation of carbohydrate biosynthetic process|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|granulocyte migration|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to catecholamine|
|response to monoamine|
|memory|
|myeloid leukocyte migration|
|cellular response to ammonium ion|
|positive regulation of small molecule metabolic process|
|regulation of blood vessel diameter|
|regulation of cellular carbohydrate metabolic process|
|regulation of tube diameter|
|regulation of tube size|
|leukocyte chemotaxis|
|learning|
|vascular process in circulatory system|
|response to ammonium ion|
|regulation of synaptic plasticity|
|regulation of carbohydrate metabolic process|
|cell chemotaxis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|learning or memory|
|regulation of blood circulation|
|cognition|
|response to light stimulus|
|second-messenger-mediated signaling|
|leukocyte migration|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|dendrite|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of small molecule metabolic process|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|inflammatory response|
|regulation of anatomical structure size|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|G protein-coupled receptor activity|
|response to organic cyclic compound|
|cell migration|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.04|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.9|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.79|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.75|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.7|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10483
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HRH1 Expression in NALM6 Cells: 1.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>