HSPA14 [The Human Chemical-Genetic Interaction Map Project]

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======= HSPA14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPA14
  * **<color #00a2e8>Official Name</color>**: heat shock protein family A (Hsp70) member 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51182|51182]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q0VDF9|Q0VDF9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPA14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPA14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610369|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity. {ECO:0000269|PubMed:16002468}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MreB Mbl|
|HSP70|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|de novo cotranslational protein folding|
|ATPase activity, coupled|
|regulation of translational fidelity|
|protein folding chaperone|
|misfolded protein binding|
|chaperone cofactor-dependent protein refolding|
|protein refolding|
|de novo posttranslational protein folding|
|de novo protein folding|
|polysome|
|ribosome|
|chaperone-mediated protein folding|
|heat shock protein binding|
|cellular response to heat|
|cytoplasmic translation|
|response to heat|
|cellular response to unfolded protein|
|unfolded protein binding|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to temperature stimulus|
|response to topologically incorrect protein|
|protein folding|
|ATPase activity|
|translation|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.17|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.03|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.72|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.74|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.83|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.86|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.98|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.09|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.22|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.23|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.42|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.57|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|3.25|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|3.39|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.62|
|[[:results:exp504|MK2206 4μM R08 exp504]]|4.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnajc2|DNAJC2]]|0.598|
|[[:human genes:w:wdr89|WDR89]]|0.447|
|[[:human genes:p:pgm3|PGM3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 46/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|5/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPA14 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>