HSPE1 [The Human Chemical-Genetic Interaction Map Project]

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======= HSPE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPE1
  * **<color #00a2e8>Official Name</color>**: heat shock protein family E (Hsp10) member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3336|3336]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61604|P61604]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chaperone cofactor-dependent protein refolding|
|de novo posttranslational protein folding|
|de novo protein folding|
|chaperone-mediated protein folding|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|chaperone binding|
|osteoblast differentiation|
|unfolded protein binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|response to unfolded protein|
|positive regulation of endopeptidase activity|
|response to topologically incorrect protein|
|positive regulation of peptidase activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein folding|
|regulation of cysteine-type endopeptidase activity|
|ossification|
|positive regulation of proteolysis|
|mitochondrial matrix|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|mitochondrion|
|regulation of hydrolase activity|
|RNA binding|
|positive regulation of catalytic activity|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.03|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.93|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.72|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.74|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.82|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.82|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.85|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.89|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.93|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.93|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.94|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.98|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.99|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.01|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.05|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.14|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.19|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.2|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.21|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.31|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.31|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.34|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.47|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.64|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 87
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPE1 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>