HYLS1 [The Human Chemical-Genetic Interaction Map Project]

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======= HYLS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HYLS1
  * **<color #00a2e8>Official Name</color>**: HYLS1 centriolar and ciliogenesis associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=219844|219844]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96M11|Q96M11]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HYLS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HYLS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610693|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein localized to the cytoplasm. Mutations in this gene are associated with hydrolethalus syndrome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|non-motile cilium|
|centriole|
|cilium|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|organelle assembly|
|plasma membrane bounded cell projection organization|
|cell projection organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.71|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.74|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.86|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.36|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.5|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|4.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.538|
|[[:human genes:o:ofd1|OFD1]]|0.515|
|[[:human genes:c:cep120|CEP120]]|0.508|
|[[:human genes:c:c2cd3|C2CD3]]|0.495|
|[[:human genes:p:pidd|PIDD]]|0.493|
|[[:human genes:c:ccdc41|CCDC41]]|0.483|
|[[:human genes:c:casp2|CASP2]]|0.481|
|[[:human genes:o:odf2|ODF2]]|0.481|
|[[:human genes:c:c16orf59|C16orf59]]|0.481|
|[[:human genes:p:pibf1|PIBF1]]|0.45|
|[[:human genes:a:ankrd26|ANKRD26]]|0.447|
|[[:human genes:c:cep76|CEP76]]|0.441|
|[[:human genes:c:c14orf80|C14orf80]]|0.43|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.426|
|[[:human genes:c:cep128|CEP128]]|0.422|
|[[:human genes:t:tubd1|TUBD1]]|0.408|
|[[:human genes:n:nin|NIN]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9530
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HYLS1 Expression in NALM6 Cells: 4.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>