HYOU1 [The Human Chemical-Genetic Interaction Map Project]

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======= HYOU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HYOU1
  * **<color #00a2e8>Official Name</color>**: hypoxia up-regulated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10525|10525]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4L1|Q9Y4L1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HYOU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HYOU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269|PubMed:10037731}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HSP70|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|
|regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|
|regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|negative regulation of cellular response to hypoxia|
|endoplasmic reticulum chaperone complex|
|regulation of cellular response to hypoxia|
|endocytic vesicle lumen|
|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|smooth endoplasmic reticulum|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of response to endoplasmic reticulum stress|
|response to ischemia|
|IRE1-mediated unfolded protein response|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of intrinsic apoptotic signaling pathway|
|chaperone binding|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|negative regulation of neuron apoptotic process|
|cellular response to topologically incorrect protein|
|regulation of intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|response to topologically incorrect protein|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|cellular response to oxygen levels|
|negative regulation of apoptotic signaling pathway|
|receptor-mediated endocytosis|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|regulation of neuron death|
|response to hypoxia|
|response to decreased oxygen levels|
|Golgi vesicle transport|
|response to oxygen levels|
|regulation of apoptotic signaling pathway|
|focal adhesion|
|negative regulation of intracellular signal transduction|
|endocytosis|
|import into cell|
|regulation of cellular response to stress|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|endoplasmic reticulum|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|ATP binding|
|intracellular transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.99|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.83|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.72|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.78|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 698/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|26/26|
|breast|26/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|19/20|
|lung|69/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 253
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HYOU1 Expression in NALM6 Cells: 9.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>