ICAM1 [The Human Chemical-Genetic Interaction Map Project]

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======= ICAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ICAM1
  * **<color #00a2e8>Official Name</color>**: intercellular adhesion molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3383|3383]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05362|P05362]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ICAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ICAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ICAM N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to sulfur dioxide|
|T cell antigen processing and presentation|
|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|membrane to membrane docking|
|receptor-mediated virion attachment to host cell|
|establishment of Sertoli cell barrier|
|T cell extravasation|
|acute inflammatory response to antigenic stimulus|
|virion attachment to host cell|
|adhesion of symbiont to host cell|
|adhesion of symbiont to host|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|establishment of endothelial intestinal barrier|
|Sertoli cell development|
|positive regulation of cellular extravasation|
|regulation of leukocyte adhesion to vascular endothelial cell|
|Sertoli cell differentiation|
|cell adhesion mediated by integrin|
|inflammatory response to antigenic stimulus|
|T cell migration|
|response to gonadotropin|
|regulation of cellular extravasation|
|cellular response to dexamethasone stimulus|
|regulation of ruffle assembly|
|negative regulation of endothelial cell apoptotic process|
|positive regulation of vasoconstriction|
|response to amphetamine|
|establishment of endothelial barrier|
|cellular response to interleukin-6|
|cellular response to alkaloid|
|immunological synapse|
|response to interleukin-6|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of nitric oxide biosynthetic process|
|cellular response to amyloid-beta|
|cellular extravasation|
|positive regulation of nitric oxide metabolic process|
|response to dexamethasone|
|negative regulation of epithelial cell apoptotic process|
|T cell mediated immunity|
|response to copper ion|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|response to amine|
|response to amyloid-beta|
|regulation of endothelial cell apoptotic process|
|endothelial cell development|
|leukocyte cell-cell adhesion|
|positive regulation of reactive oxygen species biosynthetic process|
|response to bronchodilator|
|ovarian follicle development|
|cellular response to glucocorticoid stimulus|
|regulation of nitric oxide biosynthetic process|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of vasoconstriction|
|cellular response to corticosteroid stimulus|
|negative regulation of calcium ion transport|
|T cell activation involved in immune response|
|cell aging|
|lymphocyte migration|
|cellular response to glucose stimulus|
|positive regulation of blood circulation|
|acute inflammatory response|
|cellular response to hexose stimulus|
|interferon-gamma-mediated signaling pathway|
|cellular response to monosaccharide stimulus|
|virus receptor activity|
|regulation of leukocyte mediated cytotoxicity|
|regulation of epithelial cell apoptotic process|
|cellular response to carbohydrate stimulus|
|endothelial cell differentiation|
|regulation of reactive oxygen species biosynthetic process|
|cellular glucose homeostasis|
|female gonad development|
|cellular response to ketone|
|positive regulation of actin filament polymerization|
|development of primary female sexual characteristics|
|response to antineoplastic agent|
|viral entry into host cell|
|endothelium development|
|positive regulation of reactive oxygen species metabolic process|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|regulation of cell killing|
|negative regulation of extrinsic apoptotic signaling pathway|
|entry into host|
|entry into host cell|
|female sex differentiation|
|lymphocyte activation involved in immune response|
|response to alkaloid|
|response to amino acid|
|response to ethanol|
|positive regulation of protein polymerization|
|positive regulation of leukocyte migration|
|integrin binding|
|male gonad development|
|development of primary male sexual characteristics|
|transmembrane signaling receptor activity|
|response to glucose|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|response to hexose|
|response to glucocorticoid|
|sensory perception of sound|
|negative regulation of ion transport|
|response to monosaccharide|
|response to ionizing radiation|
|regulation of cell shape|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of extrinsic apoptotic signaling pathway|
|male sex differentiation|
|interaction with host|
|response to corticosteroid|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|sensory perception of mechanical stimulus|
|vascular process in circulatory system|
|response to carbohydrate|
|cellular response to interleukin-1|
|regulation of reactive oxygen species metabolic process|
|membrane docking|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|glucose homeostasis|
|cellular response to lipopolysaccharide|
|carbohydrate homeostasis|
|cellular response to xenobiotic stimulus|
|cellular response to hypoxia|
|cellular response to steroid hormone stimulus|
|positive regulation of peptidyl-tyrosine phosphorylation|
|epithelial cell development|
|cellular response to molecule of bacterial origin|
|response to ketone|
|regulation of leukocyte migration|
|positive regulation of supramolecular fiber organization|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of plasma membrane bounded cell projection assembly|
|viral life cycle|
|regulation of cell projection assembly|
|signaling receptor activity|
|gonad development|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to biotic stimulus|
|cellular response to oxygen levels|
|development of primary sexual characteristics|
|positive regulation of leukocyte cell-cell adhesion|
|antigen processing and presentation|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|negative regulation of apoptotic signaling pathway|
|membrane raft|
|response to insulin|
|response to alcohol|
|cellular response to nutrient levels|
|T cell activation|
|cellular response to tumor necrosis factor|
|positive regulation of protein complex assembly|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|sex differentiation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|aging|
|regulation of blood circulation|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|cellular response to peptide|
|response to steroid hormone|
|cellular response to external stimulus|
|extracellular matrix organization|
|response to hypoxia|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|response to metal ion|
|regulation of cellular component size|
|leukocyte migration|
|response to oxygen levels|
|lymphocyte activation|
|regulation of metal ion transport|
|extracellular structure organization|
|regulation of actin filament-based process|
|blood circulation|
|response to peptide hormone|
|external side of plasma membrane|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|cellular response to drug|
|positive regulation of GTPase activity|
|focal adhesion|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|response to radiation|
|regulation of protein complex assembly|
|response to peptide|
|regulation of GTPase activity|
|negative regulation of transport|
|regulation of cell morphogenesis|
|response to nutrient levels|
|inflammatory response|
|positive regulation of cell migration|
|cell-cell adhesion|
|response to toxic substance|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of cell motility|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|adaptive immune response|
|cell surface|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|epithelial cell differentiation|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|viral process|
|regulation of cell projection organization|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|innate immune response|
|positive regulation of hydrolase activity|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|response to lipid|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|sensory perception|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|system process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6786
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ICAM1 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>