ICMT [The Human Chemical-Genetic Interaction Map Project]

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======= ICMT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ICMT
  * **<color #00a2e8>Official Name</color>**: isoprenylcysteine carboxyl methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23463|23463]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60725|O60725]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ICMT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ICMT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ICMT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity|
|C-terminal protein methylation|
|protein C-terminal carboxyl O-methyltransferase activity|
|C-terminal protein amino acid modification|
|protein alkylation|
|protein methylation|
|protein targeting to membrane|
|macromolecule methylation|
|establishment of protein localization to membrane|
|methylation|
|protein targeting|
|post-translational protein modification|
|protein localization to membrane|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.89|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.87|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.81|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.74|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.74|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.73|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.91|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.29|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med16|MED16]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ICMT Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>