ID2 [The Human Chemical-Genetic Interaction Map Project]

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======= ID2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ID2
  * **<color #00a2e8>Official Name</color>**: inhibitor of DNA binding 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3398|3398]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02363|Q02363]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ID2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ID2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:20861012}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endodermal digestive tract morphogenesis|
|thigmotaxis|
|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|
|epithelial cell differentiation involved in mammary gland alveolus development|
|bundle of His development|
|negative regulation of B cell differentiation|
|His-Purkinje system development|
|Peyers patch development|
|mucosal-associated lymphoid tissue development|
|enucleate erythrocyte differentiation|
|natural killer cell differentiation|
|membranous septum morphogenesis|
|cardiac conduction system development|
|positive regulation of astrocyte differentiation|
|mammary gland epithelial cell proliferation|
|locomotor rhythm|
|negative regulation of oligodendrocyte differentiation|
|cellular response to lithium ion|
|positive regulation of macrophage differentiation|
|mammary gland epithelial cell differentiation|
|mammary gland lobule development|
|embryonic digestive tract morphogenesis|
|mammary gland alveolus development|
|regulation of macrophage differentiation|
|entrainment of circadian clock by photoperiod|
|response to lithium ion|
|circadian behavior|
|negative regulation of neural precursor cell proliferation|
|rhythmic behavior|
|negative regulation of glial cell differentiation|
|photoperiodism|
|regulation of astrocyte differentiation|
|regulation of B cell differentiation|
|entrainment of circadian clock|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|positive regulation of erythrocyte differentiation|
|negative regulation of B cell activation|
|cellular senescence|
|olfactory bulb development|
|olfactory lobe development|
|embryonic digestive tract development|
|adipose tissue development|
|positive regulation of blood pressure|
|regulation of oligodendrocyte differentiation|
|ventricular septum morphogenesis|
|negative regulation of gliogenesis|
|oligodendrocyte development|
|positive regulation of glial cell differentiation|
|negative regulation of osteoblast differentiation|
|regulation of erythrocyte differentiation|
|digestive tract morphogenesis|
|negative regulation of lymphocyte differentiation|
|negative regulation of DNA binding|
|ventricular cardiac muscle tissue development|
|positive regulation of myeloid leukocyte differentiation|
|natural killer cell activation|
|mammary gland epithelium development|
|positive regulation of fat cell differentiation|
|RNA polymerase II transcription factor binding|
|circadian regulation of gene expression|
|neuron fate commitment|
|cell aging|
|regulation of glial cell differentiation|
|oligodendrocyte differentiation|
|positive regulation of gliogenesis|
|ventricular septum development|
|negative regulation of ossification|
|cardiac septum morphogenesis|
|adult locomotory behavior|
|erythrocyte differentiation|
|positive regulation of cell cycle arrest|
|metanephros development|
|positive regulation of smooth muscle cell proliferation|
|epithelial cell proliferation|
|regulation of neural precursor cell proliferation|
|erythrocyte homeostasis|
|positive regulation of myeloid cell differentiation|
|negative regulation of leukocyte differentiation|
|myeloid cell homeostasis|
|regulation of cell cycle arrest|
|glial cell development|
|cardiac septum development|
|regulation of osteoblast differentiation|
|regulation of circadian rhythm|
|regulation of myeloid leukocyte differentiation|
|regulation of gliogenesis|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|regulation of fat cell differentiation|
|regulation of DNA binding|
|ion channel binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|mammary gland development|
|digestive tract development|
|regulation of smooth muscle cell proliferation|
|negative regulation of hemopoiesis|
|circadian rhythm|
|digestive system development|
|negative regulation of lymphocyte activation|
|adult behavior|
|positive regulation of leukocyte differentiation|
|regulation of G1/S transition of mitotic cell cycle|
|cell maturation|
|protein dimerization activity|
|negative regulation of DNA-binding transcription factor activity|
|cardiac muscle tissue development|
|regulation of cell cycle G1/S phase transition|
|regulation of lymphocyte differentiation|
|negative regulation of binding|
|glial cell differentiation|
|cardiac chamber development|
|negative regulation of leukocyte activation|
|regulation of blood pressure|
|positive regulation of hemopoiesis|
|regulation of ossification|
|cellular response to metal ion|
|locomotory behavior|
|negative regulation of cell activation|
|homeostasis of number of cells|
|regulation of B cell activation|
|gliogenesis|
|cellular response to inorganic substance|
|myeloid cell differentiation|
|connective tissue development|
|regulation of myeloid cell differentiation|
|negative regulation of neuron differentiation|
|lymphocyte differentiation|
|developmental maturation|
|cell fate commitment|
|heart morphogenesis|
|telencephalon development|
|kidney development|
|mitotic cell cycle phase transition|
|regulation of leukocyte differentiation|
|rhythmic process|
|aging|
|cell cycle phase transition|
|renal system development|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|muscle tissue development|
|response to light stimulus|
|negative regulation of nervous system development|
|urogenital system development|
|leukocyte differentiation|
|transcription factor binding|
|negative regulation of cell development|
|response to metal ion|
|positive regulation of cell cycle|
|regulation of binding|
|lymphocyte activation|
|forebrain development|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|gland development|
|regulation of mitotic cell cycle phase transition|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|response to radiation|
|negative regulation of immune system process|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|regulation of lymphocyte activation|
|heart development|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|embryonic morphogenesis|
|behavior|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|immune system development|
|tube morphogenesis|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|mitotic cell cycle|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|regulation of cell cycle process|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|cell cycle process|
|neuron differentiation|
|cell activation|
|epithelium development|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ID2 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>