IDE [The Human Chemical-Genetic Interaction Map Project]

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======= IDE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IDE
  * **<color #00a2e8>Official Name</color>**: insulin degrading enzyme
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3416|3416]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14735|P14735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IDE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IDE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M16 C|
|Peptidase M16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-endorphin binding|
|insulin catabolic process|
|bradykinin catabolic process|
|insulin binding|
|cytosolic proteasome complex|
|insulin metabolic process|
|ubiquitin-dependent protein binding|
|amyloid-beta clearance by cellular catabolic process|
|ubiquitin recycling|
|regulation of aerobic respiration|
|antigen processing and presentation of endogenous peptide antigen|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|hormone catabolic process|
|determination of adult lifespan|
|amyloid-beta metabolic process|
|antigen processing and presentation of endogenous antigen|
|amyloid-beta clearance|
|positive regulation of protein oligomerization|
|peptide catabolic process|
|regulation of cellular respiration|
|multicellular organism aging|
|regulation of protein oligomerization|
|peptide binding|
|peroxisomal matrix|
|establishment of protein localization to peroxisome|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|peroxisomal transport|
|endopeptidase activity|
|virus receptor activity|
|peroxisome organization|
|amyloid-beta binding|
|insulin receptor signaling pathway|
|protein homotetramerization|
|viral entry into host cell|
|antigen processing and presentation of peptide antigen via MHC class I|
|entry into host|
|entry into host cell|
|metalloendopeptidase activity|
|protein heterooligomerization|
|peroxisome|
|drug catabolic process|
|protein tetramerization|
|interaction with host|
|regulation of generation of precursor metabolites and energy|
|cellular response to insulin stimulus|
|antigen processing and presentation of peptide antigen|
|basolateral plasma membrane|
|viral life cycle|
|hormone metabolic process|
|antigen processing and presentation|
|positive regulation of protein catabolic process|
|response to insulin|
|ATPase activity|
|positive regulation of protein complex assembly|
|cellular response to peptide hormone stimulus|
|aging|
|cellular response to peptide|
|protein homooligomerization|
|negative regulation of proteolysis|
|protein targeting|
|regulation of protein catabolic process|
|response to peptide hormone|
|external side of plasma membrane|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|response to peptide|
|drug metabolic process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|peptide metabolic process|
|regulation of hormone levels|
|proteolysis involved in cellular protein catabolic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cell surface|
|cellular protein catabolic process|
|cellular response to nitrogen compound|
|protein catabolic process|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|zinc ion binding|
|protein homodimerization activity|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|response to hormone|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|proteolysis|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|establishment of protein localization|
|homeostatic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.7|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.83|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.95|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.34|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8335
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IDE Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>