IDH1 [The Human Chemical-Genetic Interaction Map Project]

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======= IDH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IDH1
  * **<color #00a2e8>Official Name</color>**: isocitrate dehydrogenase (NADP(+)) 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3417|3417]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75874|O75874]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IDH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IDH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Iso dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isocitrate dehydrogenase (NADP+) activity|
|glyoxylate cycle|
|isocitrate metabolic process|
|regulation of phospholipid catabolic process|
|glyoxylate metabolic process|
|tricarboxylic acid metabolic process|
|NADPH regeneration|
|2-oxoglutarate metabolic process|
|regulation of phospholipid biosynthetic process|
|NADP metabolic process|
|tricarboxylic acid cycle|
|NADP binding|
|NAD binding|
|peroxisomal matrix|
|cellular aldehyde metabolic process|
|regulation of lipid catabolic process|
|glutathione metabolic process|
|tertiary granule lumen|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|aerobic respiration|
|regulation of phospholipid metabolic process|
|female gonad development|
|development of primary female sexual characteristics|
|dicarboxylic acid metabolic process|
|female sex differentiation|
|peroxisome|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|secondary alcohol metabolic process|
|cellular respiration|
|cellular carbohydrate metabolic process|
|regulation of lipid biosynthetic process|
|cellular modified amino acid metabolic process|
|gonad development|
|magnesium ion binding|
|development of primary sexual characteristics|
|energy derivation by oxidation of organic compounds|
|sex differentiation|
|cadherin binding|
|alcohol metabolic process|
|response to steroid hormone|
|protein targeting|
|sulfur compound metabolic process|
|response to oxidative stress|
|regulation of lipid metabolic process|
|generation of precursor metabolites and energy|
|reproductive structure development|
|reproductive system development|
|establishment of protein localization to organelle|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|developmental process involved in reproduction|
|regulated exocytosis|
|protein localization to organelle|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|regulation of cellular catabolic process|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|leukocyte activation|
|oxidation-reduction process|
|intracellular protein transport|
|regulation of catabolic process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|secretion|
|mitochondrion|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14444
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IDH1 Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>