IER3IP1 [The Human Chemical-Genetic Interaction Map Project]

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======= IER3IP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IER3IP1
  * **<color #00a2e8>Official Name</color>**: immediate early response 3 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51124|51124]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5U9|Q9Y5U9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IER3IP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IER3IP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609382|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Yos1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of fibroblast apoptotic process|
|COPII-coated ER to Golgi transport vesicle|
|integral component of Golgi membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|endoplasmic reticulum|
|intracellular transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.16|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.3|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.27|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.06|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.91|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.83|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.74|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.74|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.76|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.9|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.04|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.05|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.07|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.1|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.16|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.36|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.72|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.78|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.82|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yipf5|YIPF5]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13885
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IER3IP1 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>