IFNA21 [The Human Chemical-Genetic Interaction Map Project]

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======= IFNA21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFNA21
  * **<color #00a2e8>Official Name</color>**: interferon alpha 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3452|3452]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01568|P01568]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFNA21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFNA21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147584|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Interferon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytokine receptor binding|
|type I interferon receptor binding|
|positive regulation of peptidyl-serine phosphorylation of STAT protein|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|natural killer cell activation involved in immune response|
|B cell proliferation|
|response to exogenous dsRNA|
|response to dsRNA|
|natural killer cell activation|
|T cell activation involved in immune response|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|leukocyte proliferation|
|positive regulation of peptidyl-serine phosphorylation|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|B cell activation|
|cytokine activity|
|defense response to virus|
|T cell activation|
|lymphocyte differentiation|
|response to virus|
|blood coagulation|
|coagulation|
|hemostasis|
|leukocyte differentiation|
|humoral immune response|
|lymphocyte activation|
|wound healing|
|regulation of body fluid levels|
|cell population proliferation|
|hemopoiesis|
|response to wounding|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|cytokine-mediated signaling pathway|
|innate immune response|
|response to organic cyclic compound|
|leukocyte activation|
|defense response to other organism|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19020
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFNA21 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>