IFNA2 [The Human Chemical-Genetic Interaction Map Project]

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======= IFNA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFNA2
  * **<color #00a2e8>Official Name</color>**: interferon alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3440|3440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01563|P01563]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFNA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFNA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147562|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Produced by macrophages, IFN-alpha have antiviral activities.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Interferon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-5 secretion|
|negative regulation of T-helper 2 cell cytokine production|
|negative regulation of interleukin-13 secretion|
|negative regulation of interleukin-5 production|
|negative regulation of interleukin-13 production|
|regulation of interleukin-5 secretion|
|negative regulation of T cell cytokine production|
|regulation of interleukin-13 secretion|
|regulation of T-helper 2 cell cytokine production|
|negative regulation of type 2 immune response|
|type I interferon receptor binding|
|negative regulation of T cell mediated immunity|
|negative regulation of viral entry into host cell|
|positive regulation of peptidyl-serine phosphorylation of STAT protein|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|regulation of interleukin-5 production|
|regulation of interleukin-13 production|
|natural killer cell activation involved in immune response|
|negative regulation of cytokine production involved in immune response|
|regulation of type 2 immune response|
|regulation of viral entry into host cell|
|regulation of T cell cytokine production|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|B cell proliferation|
|negative regulation of T cell differentiation|
|response to exogenous dsRNA|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte mediated immunity|
|response to dsRNA|
|negative regulation of lymphocyte differentiation|
|natural killer cell activation|
|T cell activation involved in immune response|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|negative regulation of cytokine secretion|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of T cell mediated immunity|
|response to type I interferon|
|regulation of tyrosine phosphorylation of STAT protein|
|negative regulation of viral life cycle|
|lymphocyte proliferation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of cytokine production involved in immune response|
|mononuclear cell proliferation|
|positive regulation of receptor signaling pathway via STAT|
|negative regulation of viral process|
|leukocyte proliferation|
|negative regulation of leukocyte differentiation|
|positive regulation of peptidyl-serine phosphorylation|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of protein secretion|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|regulation of viral life cycle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|B cell activation|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|cytokine activity|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|defense response to virus|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of secretion|
|T cell activation|
|lymphocyte differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|response to virus|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of T cell activation|
|leukocyte differentiation|
|humoral immune response|
|collagen-containing extracellular matrix|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of protein secretion|
|regulation of immune effector process|
|wound healing|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|regulation of lymphocyte activation|
|cell population proliferation|
|hemopoiesis|
|response to wounding|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|programmed cell death|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|cell death|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18715
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFNA2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>