IFT20 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= IFT20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFT20
  * **<color #00a2e8>Official Name</color>**: intraflagellar transport 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90410|90410]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IY31|Q8IY31]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFT20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFT20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614394|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000269|PubMed:16775004}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|opsin transport|
|kinociliary basal body|
|opsin binding|
|dendrite terminus|
|regulation of platelet-derived growth factor receptor-alpha signaling pathway|
|photoreceptor cell outer segment organization|
|intraciliary transport particle B|
|regulation of platelet-derived growth factor receptor signaling pathway|
|establishment of tissue polarity|
|establishment of planar polarity|
|inner ear receptor cell stereocilium organization|
|protein localization to Golgi apparatus|
|centrosome localization|
|microtubule organizing center localization|
|stereocilium|
|ciliary base|
|regulation of autophagosome assembly|
|photoreceptor connecting cilium|
|intraciliary transport involved in cilium assembly|
|inner ear receptor cell development|
|regulation of vacuole organization|
|morphogenesis of a polarized epithelium|
|ciliary tip|
|photoreceptor cell development|
|protein localization to cilium|
|visual learning|
|cochlea development|
|intraciliary transport|
|inner ear receptor cell differentiation|
|visual behavior|
|photoreceptor cell differentiation|
|mechanoreceptor differentiation|
|photoreceptor outer segment|
|microvillus|
|cis-Golgi network|
|microtubule-based protein transport|
|protein transport along microtubule|
|smoothened signaling pathway|
|neural precursor cell proliferation|
|associative learning|
|regulation of cilium assembly|
|cardiac muscle cell differentiation|
|motile cilium|
|cardiocyte differentiation|
|centriole|
|learning|
|Rab GTPase binding|
|transport along microtubule|
|cardiac muscle tissue development|
|regulation of macroautophagy|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|protein localization to plasma membrane|
|inner ear development|
|cilium|
|regulation of plasma membrane bounded cell projection assembly|
|striated muscle cell differentiation|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|ear development|
|protein localization to cell periphery|
|muscle cell differentiation|
|protein-containing complex localization|
|learning or memory|
|kidney development|
|microtubule-based movement|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|renal system development|
|muscle tissue development|
|cognition|
|response to light stimulus|
|urogenital system development|
|regulation of autophagy|
|cilium assembly|
|regulation of Wnt signaling pathway|
|cilium organization|
|morphogenesis of an epithelium|
|response to radiation|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|muscle structure development|
|protein localization to membrane|
|centrosome|
|heart development|
|spermatogenesis|
|sensory organ development|
|cell population proliferation|
|male gamete generation|
|tissue morphogenesis|
|behavior|
|organelle localization|
|Golgi membrane|
|neuron projection development|
|microtubule-based process|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|protein localization to organelle|
|organelle assembly|
|neuron development|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|circulatory system development|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|intracellular protein transport|
|regulation of catabolic process|
|multi-organism reproductive process|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|regulation of organelle organization|
|nervous system process|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13636
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFT20 Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>