IGF1 [The Human Chemical-Genetic Interaction Map Project]

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======= IGF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGF1
  * **<color #00a2e8>Official Name</color>**: insulin like growth factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3479|3479]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05019|P05019]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down- stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309). {ECO:0000250|UniProtKB:P05017, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:23243309, ECO:0000269|PubMed:23696648, ECO:0000269|PubMed:24132240}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Insulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of trophectodermal cell proliferation|
|regulation of trophectodermal cell proliferation|
|negative regulation of vascular associated smooth muscle cell apoptotic process|
|insulin-like growth factor binding protein complex|
|glycolate metabolic process|
|negative regulation of oocyte development|
|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|
|insulin-like growth factor ternary complex|
|alphav-beta3 integrin-IGF-1-IGF1R complex|
|negative regulation of oogenesis|
|myoblast proliferation|
|bone mineralization involved in bone maturation|
|negative regulation of smooth muscle cell apoptotic process|
|positive regulation of cell growth involved in cardiac muscle cell development|
|regulation of vascular associated smooth muscle cell apoptotic process|
|regulation of oocyte development|
|regulation of oogenesis|
|negative regulation of neuroinflammatory response|
|positive regulation of insulin-like growth factor receptor signaling pathway|
|negative regulation of amyloid-beta formation|
|insulin-like growth factor receptor signaling pathway|
|ossification involved in bone maturation|
|negative regulation of amyloid precursor protein catabolic process|
|positive regulation of calcineurin-NFAT signaling cascade|
|insulin-like growth factor receptor binding|
|positive regulation of calcineurin-mediated signaling|
|positive regulation of glycogen biosynthetic process|
|bone maturation|
|regulation of cell growth involved in cardiac muscle cell development|
|positive regulation of glycogen metabolic process|
|positive regulation of cardiac muscle cell differentiation|
|negative regulation of release of cytochrome c from mitochondria|
|positive regulation of glycoprotein biosynthetic process|
|animal organ maturation|
|insulin receptor binding|
|positive regulation of activated T cell proliferation|
|positive regulation of glycoprotein metabolic process|
|regulation of insulin-like growth factor receptor signaling pathway|
|positive regulation of glycolytic process|
|regulation of smooth muscle cell apoptotic process|
|positive regulation of transcription regulatory region DNA binding|
|exocytic vesicle|
|myotube cell development|
|regulation of amyloid-beta formation|
|negative regulation of interleukin-1 beta production|
|positive regulation of cardiocyte differentiation|
|ERK1 and ERK2 cascade|
|regulation of glycogen biosynthetic process|
|regulation of glucan biosynthetic process|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of muscle hypertrophy|
|regulation of neuroinflammatory response|
|muscle hypertrophy|
|activation of protein kinase B activity|
|negative regulation of interleukin-1 production|
|positive regulation of cardiac muscle tissue growth|
|regulation of amyloid precursor protein catabolic process|
|phosphatidylinositol 3-kinase signaling|
|positive regulation of vascular smooth muscle cell proliferation|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|skeletal muscle tissue regeneration|
|myoblast differentiation|
|regulation of glycogen metabolic process|
|regulation of cardiac muscle cell differentiation|
|regulation of activated T cell proliferation|
|positive regulation of smooth muscle cell migration|
|regulation of polysaccharide biosynthetic process|
|negative regulation of muscle cell apoptotic process|
|positive regulation of embryonic development|
|positive regulation of glucose import|
|positive regulation of heart growth|
|protein kinase B signaling|
|positive regulation of glucose metabolic process|
|cellular response to amyloid-beta|
|regulation of glycoprotein biosynthetic process|
|positive regulation of calcium-mediated signaling|
|regulation of polysaccharide metabolic process|
|positive regulation of glucose transmembrane transport|
|positive regulation of cardiac muscle tissue development|
|regulation of glycoprotein metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of organ growth|
|regulation of release of cytochrome c from mitochondria|
|bone mineralization|
|response to amyloid-beta|
|positive regulation of fibroblast proliferation|
|regulation of cardiocyte differentiation|
|regulation of vascular smooth muscle cell proliferation|
|regulation of transcription regulatory region DNA binding|
|positive regulation of mitotic nuclear division|
|negative regulation of mitochondrion organization|
|regulation of glucose import|
|positive regulation of DNA binding|
|regulation of cardiac muscle hypertrophy|
|negative regulation of reproductive process|
|myotube differentiation|
|positive regulation of osteoblast differentiation|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of cardiac muscle tissue growth|
|positive regulation of striated muscle cell differentiation|
|negative regulation of tumor necrosis factor production|
|regulation of muscle hypertrophy|
|regulation of smooth muscle cell migration|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|tissue regeneration|
|positive regulation of Ras protein signal transduction|
|regulation of heart growth|
|regulation of multicellular organism growth|
|positive regulation of nuclear division|
|proteoglycan biosynthetic process|
|platelet alpha granule lumen|
|regulation of muscle cell apoptotic process|
|positive regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|phosphatidylinositol-mediated signaling|
|positive regulation of small GTPase mediated signal transduction|
|regulation of glucose transmembrane transport|
|inositol lipid-mediated signaling|
|primary alcohol metabolic process|
|regulation of cardiac muscle tissue development|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of interleukin-1 beta production|
|regulation of fibroblast proliferation|
|positive regulation of ossification|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of muscle adaptation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of muscle cell differentiation|
|regulation of carbohydrate catabolic process|
|positive regulation of receptor signaling pathway via STAT|
|proteoglycan metabolic process|
|biomineralization|
|biomineral tissue development|
|regulation of organ growth|
|positive regulation of T cell proliferation|
|regulation of carbohydrate biosynthetic process|
|regulation of interleukin-1 production|
|regulation of calcium-mediated signaling|
|hormone activity|
|regulation of striated muscle cell differentiation|
|negative regulation of extrinsic apoptotic signaling pathway|
|response to heat|
|regulation of osteoblast differentiation|
|regulation of glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|regulation of ATP metabolic process|
|regulation of DNA binding|
|regulation of embryonic development|
|platelet degranulation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|integrin binding|
|regulation of striated muscle tissue development|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|anatomical structure maturation|
|striated muscle cell development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|maintenance of cell number|
|negative regulation of inflammatory response|
|positive regulation of leukocyte proliferation|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|negative regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor production|
|muscle cell development|
|positive regulation of mitotic cell cycle|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of muscle cell differentiation|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|regeneration|
|regulation of T cell proliferation|
|regulation of generation of precursor metabolites and energy|
|regulation of reproductive process|
|growth factor activity|
|positive regulation of cell growth|
|regulation of mitotic nuclear division|
|positive regulation of developmental growth|
|response to temperature stimulus|
|protein stabilization|
|positive regulation of binding|
|regulation of mitochondrion organization|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of nuclear division|
|bone development|
|striated muscle cell differentiation|
|positive regulation of T cell activation|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|negative regulation of apoptotic signaling pathway|
|regulation of muscle system process|
|developmental maturation|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|Ras protein signal transduction|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|ossification|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of cell cycle process|
|regulation of protein stability|
|positive regulation of peptide secretion|
|muscle organ development|
|regulation of leukocyte cell-cell adhesion|
|muscle system process|
|alcohol metabolic process|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|glycoprotein biosynthetic process|
|cellular response to peptide|
|activation of protein kinase activity|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|negative regulation of organelle organization|
|regulation of binding|
|positive regulation of cell cycle|
|glycoprotein metabolic process|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of cell growth|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|positive regulation of secretion|
|organic hydroxy compound metabolic process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|response to peptide|
|muscle structure development|
|wound healing|
|skeletal system development|
|regulation of peptide secretion|
|drug metabolic process|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|monocarboxylic acid metabolic process|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|cell population proliferation|
|regulation of transmembrane transport|
|response to wounding|
|positive regulation of kinase activity|
|regulation of system process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of growth|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|regulation of defense response|
|regulation of multi-organism process|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6132
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGF1 Expression in NALM6 Cells: 2.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>