IGLL1 [The Human Chemical-Genetic Interaction Map Project]

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======= IGLL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGLL1
  * **<color #00a2e8>Official Name</color>**: immunoglobulin lambda like polypeptide 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3543|3543]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15814|P15814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGLL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGLL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Critical for B-cell development. {ECO:0000269|PubMed:9419212}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immunoglobulin complex, circulating|
|immunoglobulin receptor binding|
|phagocytosis, recognition|
|B cell receptor signaling pathway|
|phagocytosis, engulfment|
|plasma membrane invagination|
|antigen binding|
|membrane invagination|
|complement activation, classical pathway|
|positive regulation of B cell activation|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|immunoglobulin mediated immune response|
|regulation of B cell activation|
|B cell mediated immunity|
|cell recognition|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|antigen receptor-mediated signaling pathway|
|phagocytosis|
|defense response to bacterium|
|humoral immune response|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|external side of plasma membrane|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of lymphocyte activation|
|endocytosis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|import into cell|
|response to bacterium|
|innate immune response|
|leukocyte mediated immunity|
|membrane organization|
|positive regulation of immune response|
|defense response to other organism|
|cell migration|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|movement of cell or subcellular component|
|regulation of immune system process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.17|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.28|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.07|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.89|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.89|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.72|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.85|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.88|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.89|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.89|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.94|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.94|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.96|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.24|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.49|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.53|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.75|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.79|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.84|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.04|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:syk|SYK]]|0.753|
|[[:human genes:r:rhoh|RHOH]]|0.738|
|[[:human genes:c:cd79a|CD79A]]|0.714|
|[[:human genes:e:ergic1|ERGIC1]]|0.704|
|[[:human genes:c:cd79b|CD79B]]|0.679|
|[[:human genes:c:cd19|CD19]]|0.674|
|[[:human genes:p:pik3cd|PIK3CD]]|0.667|
|[[:human genes:c:cd81|CD81]]|0.568|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.54|
|[[:human genes:a:akt2|AKT2]]|0.525|
|[[:human genes:r:rictor|RICTOR]]|0.507|
|[[:human genes:g:ganab|GANAB]]|0.484|
|[[:human genes:m:mmd|MMD]]|0.433|
|[[:human genes:v:vezf1|VEZF1]]|0.427|
|[[:human genes:s:ssr2|SSR2]]|0.422|
|[[:human genes:c:cmtm7|CMTM7]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2053
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGLL1 Expression in NALM6 Cells: 9.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>