IL12RB1 [The Human Chemical-Genetic Interaction Map Project]

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======= IL12RB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL12RB1
  * **<color #00a2e8>Official Name</color>**: interleukin 12 receptor subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3594|3594]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42701|P42701]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL12RB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL12RB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601604|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. {ECO:0000269|PubMed:12023369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-12 receptor complex|
|interleukin-12 receptor activity|
|interleukin-23 binding|
|interleukin-23 receptor complex|
|interleukin-23 receptor activity|
|positive regulation of T-helper 17 cell lineage commitment|
|interleukin-12 receptor binding|
|regulation of T-helper 17 cell lineage commitment|
|positive regulation of memory T cell differentiation|
|positive regulation of T-helper 17 cell differentiation|
|interleukin-23-mediated signaling pathway|
|positive regulation of cell fate commitment|
|regulation of memory T cell differentiation|
|positive regulation of T-helper 17 type immune response|
|regulation of T-helper 17 cell differentiation|
|regulation of T-helper 17 type immune response|
|positive regulation of T-helper 1 type immune response|
|positive regulation of T-helper cell differentiation|
|positive regulation of activated T cell proliferation|
|positive regulation of T cell mediated cytotoxicity|
|positive regulation of defense response to virus by host|
|regulation of T-helper 1 type immune response|
|regulation of cell fate commitment|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of T cell mediated cytotoxicity|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|regulation of activated T cell proliferation|
|regulation of defense response to virus by host|
|cytokine binding|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|interleukin-12-mediated signaling pathway|
|cytokine receptor activity|
|cellular response to interleukin-12|
|positive regulation of T cell mediated immunity|
|response to interleukin-12|
|positive regulation of leukocyte mediated cytotoxicity|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of interferon-gamma production|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|regulation of defense response to virus|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of T cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|regulation of lymphocyte differentiation|
|response to interferon-gamma|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|receptor complex|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|defense response to other organism|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|regulation of response to stress|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL12RB1 Expression in NALM6 Cells: 3.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>