IL17F [The Human Chemical-Genetic Interaction Map Project]

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======= IL17F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL17F
  * **<color #00a2e8>Official Name</color>**: interleukin 17F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112744|112744]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PD4|Q96PD4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL17F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL17F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606496|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TNI7, ECO:0000269|PubMed:11574464, ECO:0000269|PubMed:11591732, ECO:0000269|PubMed:11591768, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lymphotoxin A biosynthetic process|
|lymphotoxin A production|
|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|
|response to interleukin-17|
|cellular response to interleukin-17|
|interleukin-17-mediated signaling pathway|
|tumor necrosis factor superfamily cytokine production|
|cytokine receptor binding|
|cytokine biosynthetic process|
|regulation of granulocyte macrophage colony-stimulating factor production|
|cytokine metabolic process|
|regulation of interleukin-8 biosynthetic process|
|positive regulation of cytokine production involved in inflammatory response|
|regulation of interleukin-2 biosynthetic process|
|regulation of interleukin-6 biosynthetic process|
|positive regulation of interleukin-6 secretion|
|regulation of cytokine production involved in inflammatory response|
|cytokine binding|
|regulation of interleukin-2 production|
|regulation of interleukin-8 production|
|positive regulation of interleukin-6 production|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of cytokine biosynthetic process|
|regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of vasculature development|
|regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|cytokine production|
|cartilage development|
|cytokine activity|
|regulation of cytokine secretion|
|connective tissue development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of protein secretion|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|regulation of vasculature development|
|regulation of inflammatory response|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|skeletal system development|
|inflammatory response|
|positive regulation of response to external stimulus|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|protein homodimerization activity|
|negative regulation of developmental process|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|defense response|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11223
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL17F Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>