IL17RA [The Human Chemical-Genetic Interaction Map Project]

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======= IL17RA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL17RA
  * **<color #00a2e8>Official Name</color>**: interleukin 17 receptor A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23765|23765]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96F46|Q96F46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL17RA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL17RA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). {ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:9367539}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SEFIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibroblast activation|
|positive regulation of interleukin-23 production|
|positive regulation of interleukin-13 secretion|
|positive regulation of interleukin-5 secretion|
|interleukin-17 receptor activity|
|interleukin-17-mediated signaling pathway|
|regulation of interleukin-23 production|
|cellular response to interleukin-17|
|regulation of interleukin-5 secretion|
|response to interleukin-17|
|regulation of interleukin-13 secretion|
|positive regulation of interleukin-5 production|
|positive regulation of interleukin-13 production|
|positive regulation of cytokine production involved in inflammatory response|
|regulation of interleukin-13 production|
|regulation of interleukin-5 production|
|defense response to fungus|
|regulation of cytokine production involved in inflammatory response|
|response to fungus|
|granulocyte chemotaxis|
|granulocyte migration|
|myeloid leukocyte migration|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|leukocyte chemotaxis|
|regulation of cytokine secretion|
|cell chemotaxis|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|signaling receptor binding|
|regulation of inflammatory response|
|leukocyte migration|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|chemotaxis|
|taxis|
|positive regulation of response to external stimulus|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|defense response to other organism|
|cell migration|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|cell activation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|movement of cell or subcellular component|
|positive regulation of multicellular organismal process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.467|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8248
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL17RA Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>