IL1RAPL1 [The Human Chemical-Genetic Interaction Map Project]

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======= IL1RAPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL1RAPL1
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor accessory protein like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11141|11141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZN1|Q9NZN1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1RAPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1RAPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300206|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity). {ECO:0000250|UniProtKB:P59823, ECO:0000250|UniProtKB:P59824, ECO:0000269|PubMed:12783849, ECO:0000269|PubMed:15123616}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-1 binding|
|trans-synaptic signaling by trans-synaptic complex|
|presynaptic membrane assembly|
|presynaptic membrane organization|
|presynapse assembly|
|presynapse organization|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|negative regulation of exocytosis|
|membrane assembly|
|positive regulation of dendrite morphogenesis|
|membrane biogenesis|
|voltage-gated calcium channel activity|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|positive regulation of synapse assembly|
|positive regulation of dendrite development|
|regulation of dendrite morphogenesis|
|synapse assembly|
|regulation of postsynapse organization|
|regulation of synapse assembly|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|negative regulation of secretion by cell|
|regulation of synapse organization|
|regulation of exocytosis|
|regulation of synapse structure or activity|
|negative regulation of secretion|
|calcium ion transport|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse organization|
|positive regulation of neuron projection development|
|divalent metal ion transport|
|axon|
|divalent inorganic cation transport|
|regulation of cell morphogenesis involved in differentiation|
|signaling receptor binding|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|dendrite|
|trans-synaptic signaling|
|synaptic signaling|
|positive regulation of neurogenesis|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|cation transport|
|membrane organization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|cell-cell signaling|
|positive regulation of cellular component organization|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17633
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL1RAPL1 Expression in NALM6 Cells: -0.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>