IL20RB [The Human Chemical-Genetic Interaction Map Project]

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======= IL20RB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL20RB
  * **<color #00a2e8>Official Name</color>**: interleukin 20 receptor subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53833|53833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXL0|Q6UXL0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL20RB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL20RB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Interfer-bind|
|Tissue fac|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of type IV hypersensitivity|
|negative regulation of hypersensitivity|
|regulation of type IV hypersensitivity|
|interleukin-20 binding|
|negative regulation of acute inflammatory response to antigenic stimulus|
|immune response-inhibiting signal transduction|
|regulation of hypersensitivity|
|negative regulation of acute inflammatory response|
|negative regulation of inflammatory response to antigenic stimulus|
|regulation of acute inflammatory response to antigenic stimulus|
|negative regulation of T cell mediated immunity|
|negative regulation of interleukin-2 production|
|positive regulation of interleukin-4 production|
|inflammatory response to antigenic stimulus|
|regulation of inflammatory response to antigenic stimulus|
|regulation of interleukin-4 production|
|homeostasis of number of cells within a tissue|
|negative regulation of interferon-gamma production|
|positive regulation of interleukin-10 production|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of acute inflammatory response|
|negative regulation of adaptive immune response|
|cytokine receptor activity|
|negative regulation of leukocyte mediated immunity|
|regulation of interleukin-10 production|
|regulation of interleukin-2 production|
|negative regulation of T cell proliferation|
|regulation of T cell mediated immunity|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|regulation of interferon-gamma production|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of inflammatory response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|tissue homeostasis|
|negative regulation of cell activation|
|homeostasis of number of cells|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|regulation of inflammatory response|
|anatomical structure homeostasis|
|negative regulation of response to external stimulus|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of immune effector process|
|inflammatory response|
|regulation of lymphocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of defense response|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|defense response|
|regulation of response to stress|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12692
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL20RB Expression in NALM6 Cells: 0.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>