IL5 [The Human Chemical-Genetic Interaction Map Project]

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======= IL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL5
  * **<color #00a2e8>Official Name</color>**: interleukin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3567|3567]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05113|P05113]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-5 receptor binding|
|regulation of eosinophil differentiation|
|positive regulation of eosinophil differentiation|
|positive regulation of granulocyte differentiation|
|positive regulation of immunoglobulin secretion|
|positive regulation of podosome assembly|
|regulation of granulocyte differentiation|
|regulation of podosome assembly|
|regulation of immunoglobulin secretion|
|positive regulation of B cell proliferation|
|positive regulation of immunoglobulin production|
|positive regulation of myeloid leukocyte differentiation|
|regulation of B cell proliferation|
|regulation of immunoglobulin production|
|positive regulation of organelle assembly|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of myeloid cell differentiation|
|positive regulation of production of molecular mediator of immune response|
|regulation of myeloid leukocyte differentiation|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte proliferation|
|regulation of production of molecular mediator of immune response|
|positive regulation of leukocyte differentiation|
|growth factor activity|
|positive regulation of B cell activation|
|cytokine activity|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of immune effector process|
|regulation of organelle assembly|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|positive regulation of peptide secretion|
|positive regulation of lymphocyte activation|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|regulation of peptide secretion|
|inflammatory response|
|regulation of lymphocyte activation|
|positive regulation of cellular component biogenesis|
|positive regulation of cell development|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|positive regulation of cell population proliferation|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|defense response|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16713
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL5 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>