IMPAD1 [The Human Chemical-Genetic Interaction Map Project]

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======= IMPAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BPNT2
  * **<color #00a2e8>Official Name</color>**: 3'(2'), 5'-bisphosphate nucleotidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54928|54928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX62|Q9NX62]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IMPAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IMPAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Inositol P|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-nucleotidase activity|
|3(2),5-bisphosphate nucleotidase activity|
|inositol monophosphate 1-phosphatase activity|
|inositol biosynthetic process|
|inositol monophosphate 3-phosphatase activity|
|inositol monophosphate 4-phosphatase activity|
|inositol metabolic process|
|3-phosphoadenosine 5-phosphosulfate metabolic process|
|purine ribonucleoside bisphosphate metabolic process|
|replacement ossification|
|endochondral ossification|
|chondroitin sulfate metabolic process|
|chondrocyte development|
|chondroitin sulfate proteoglycan metabolic process|
|phosphatidylinositol phosphorylation|
|cellular carbohydrate biosynthetic process|
|polyol biosynthetic process|
|embryonic digit morphogenesis|
|lipid phosphorylation|
|endochondral bone morphogenesis|
|chondrocyte differentiation|
|post-embryonic development|
|proteoglycan metabolic process|
|Golgi lumen|
|mucopolysaccharide metabolic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|bone morphogenesis|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|carbohydrate biosynthetic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|appendage morphogenesis|
|limb morphogenesis|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|phosphatidylinositol metabolic process|
|cellular carbohydrate metabolic process|
|cartilage development|
|limb development|
|appendage development|
|organic hydroxy compound biosynthetic process|
|bone development|
|lipid modification|
|connective tissue development|
|skeletal system morphogenesis|
|ossification|
|nuclear body|
|glycerophospholipid metabolic process|
|dephosphorylation|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|glycoprotein metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|skeletal system development|
|nucleobase-containing small molecule metabolic process|
|embryonic morphogenesis|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|embryo development|
|Golgi apparatus|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|phosphorylation|
|cell development|
|small molecule metabolic process|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16650
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IMPAD1 Expression in NALM6 Cells: 7.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>