INA [The Human Chemical-Genetic Interaction Map Project]

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======= INA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INA
  * **<color #00a2e8>Official Name</color>**: internexin neuronal intermediate filament protein alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9118|9118]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16352|Q16352]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605338|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament head|
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic intermediate filament cytoskeleton organization|
|structural constituent of postsynaptic intermediate filament cytoskeleton|
|structural constituent of postsynaptic actin cytoskeleton|
|neurofilament|
|neurofilament cytoskeleton organization|
|postsynaptic actin cytoskeleton organization|
|postsynaptic cytoskeleton organization|
|substantia nigra development|
|intermediate filament cytoskeleton|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|neural nucleus development|
|cytoplasmic ribonucleoprotein granule|
|Schaffer collateral - CA1 synapse|
|postsynapse|
|midbrain development|
|postsynapse organization|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|structural constituent of cytoskeleton|
|nuclear membrane|
|synapse organization|
|actin cytoskeleton organization|
|actin filament-based process|
|brain development|
|head development|
|central nervous system development|
|cellular response to cytokine stimulus|
|response to cytokine|
|cytoskeleton organization|
|extracellular space|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INA Expression in NALM6 Cells: 2.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>