ING1 [The Human Chemical-Genetic Interaction Map Project]

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======= ING1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ING1
  * **<color #00a2e8>Official Name</color>**: inhibitor of growth family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3621|3621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UK53|Q9UK53]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ING1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ING1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601566|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|ING|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methylated histone binding|
|negative regulation of cell growth|
|negative regulation of growth|
|regulation of cell growth|
|regulation of growth|
|negative regulation of cell population proliferation|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.63|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.46|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.34|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.21|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.19|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.12|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.08|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.05|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.03|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.02|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.92|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.9|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.83|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.75|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.73|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.72|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.72|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.81|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.83|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.97|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.04|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.05|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.06|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.07|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.14|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.17|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.23|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.33|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.55|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.59|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|3.05|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.3|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|3.38|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|4.16|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|4.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sap130|SAP130]]|0.727|
|[[:human genes:b:brms1|BRMS1]]|0.705|
|[[:human genes:s:sin3a|SIN3A]]|0.623|
|[[:human genes:s:suds3|SUDS3]]|0.568|
|[[:human genes:i:ing2|ING2]]|0.514|
|[[:human genes:a:arid4b|ARID4B]]|0.489|
|[[:human genes:f:fam204a|FAM204A]]|0.464|
|[[:human genes:t:tspyl1|TSPYL1]]|0.456|
|[[:human genes:h:hexim1|HEXIM1]]|0.442|
|[[:human genes:b:brd1|BRD1]]|0.435|
|[[:human genes:r:rbm26|RBM26]]|0.408|
|[[:human genes:f:fam60a|FAM60A]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18373
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ING1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>