ING5 [The Human Chemical-Genetic Interaction Map Project]

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======= ING5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ING5
  * **<color #00a2e8>Official Name</color>**: inhibitor of growth family member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84289|84289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WYH8|Q8WYH8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ING5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ING5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608525|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ING|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MOZ/MORF histone acetyltransferase complex|
|histone H3 acetylation|
|methylated histone binding|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|positive regulation of apoptotic signaling pathway|
|regulation of signal transduction by p53 class mediator|
|protein acylation|
|DNA replication|
|negative regulation of growth|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.7|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.2|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.08|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.94|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.86|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.84|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.76|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.77|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.77|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.79|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.8|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.83|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.88|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.93|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.97|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.16|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.19|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.23|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.48|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.56|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13l|MED13L]]|0.51|
|[[:human genes:m:med13|MED13]]|0.509|
|[[:human genes:z:znf644|ZNF644]]|0.501|
|[[:human genes:e:ehmt2|EHMT2]]|0.463|
|[[:human genes:m:meaf6|MEAF6]]|0.448|
|[[:human genes:z:zc3h18|ZC3H18]]|0.443|
|[[:human genes:b:brpf1|BRPF1]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1589
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ING5 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>