INO80C [The Human Chemical-Genetic Interaction Map Project]

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======= INO80C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INO80C
  * **<color #00a2e8>Official Name</color>**: INO80 complex subunit C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=125476|125476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PI98|Q6PI98]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INO80C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INO80C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|YL1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ino80 complex|
|MLL1 complex|
|fibrillar center|
|chromatin remodeling|
|DNA recombination|
|protein deubiquitination|
|protein modification by small protein removal|
|DNA repair|
|chromatin organization|
|DNA metabolic process|
|molecular function|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|proteolysis|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.19|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.92|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.77|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.79|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.82|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.87|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.89|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.91|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.92|
|[[:results:exp17|DABN 20μM R00 exp17]]|2|
|[[:results:exp135|MS023 7μM R03 exp135]]|2|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.09|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.1|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.12|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.13|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.23|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.26|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.27|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.29|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.4|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.59|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.72|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.89|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.89|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.22|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:actr5|ACTR5]]|0.624|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.581|
|[[:human genes:n:nfrkb|NFRKB]]|0.488|
|[[:human genes:p:pih1d1|PIH1D1]]|0.439|
|[[:human genes:u:uchl5|UCHL5]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6705
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INO80C Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>